Abstract: Objective To review the clinical applications of Radix Aconiti Lateralis Preparata at large doses, and provide reference for related treatments. Methods Based on the dosage of Radix Aconiti Lateralis Preparata specified in the Pharmacopoeia of the People's Republic of China (2020 Edition) and by means of literature review, the current usage of Radix Aconiti Lateralis Preparata at large doses was investigated. Treatments within different dosage ranges, in different stages and for different diseases were discussed in terms of toxicology, applications, studies on ancient prescriptions, modern clinical applications, different dosages and real cases. Results Large dosages of Radix Aconiti Lateralis Preparata had special effect. The dosage of Radix Aconiti Lateralis Preparata, which varied greatly depending on the stage and type of the disease, ranged from 30 to 200 g or even exceeded 200 g as was recorded in literature. However, most of the dosages ranged from 30 to 60 g. When used, fuzi had to be processed or decocted in water. When the prescribed range was 3 to 15 g stated in the Pharmacopoeia of the People's Republic of China, its toxicity was usually reduced via compatibility, processing or otherwise. Conclusion The use of high-dose Radix Aconiti Lateralis Preparata has been widely reported, and the therapeutic effect against a variety of diseases is remarkable. However, Fuzi should still be used with caution in clinic to ensure safety.

Key words: Radix Aconiti Lateralis Preparata (fuzi), large dose, clinical symptoms, ancient, compatibility, processing, detoxification