Abstract: Objective To study the toxicity of Zanthoxylum Bungeanum based on herbal literature and analyze the influence of origin, places of production, medicinal properties, and processing methods on the toxicity of Zanthoxylum bungeanum so as to contribute to the clinical application of Zanthoxylum bungeanum. Methods The herbal textual research method was used to sort out the ancient records of toxicity of Zanthoxylum bungeanum, and the related influencing factors were analyzed. Results Zanthoxylum bungeanum documented in ancient books could be divided into two categories: medicinal and edible. The varieties of Zanthoxylum bungeanum used as medicines were more toxic than those used as foods. Zanthoxylum bungeanum had hot medicinal properties and a pungent smell. Excessive use could cause such adverse reactions as asthma, toothache and clouded vision. The toxicity of Zanthoxylum bungeanum could be reduced by heating, cleaning, and preparing it with other herbs. Conclusion The toxicity of Zanthoxylum bungeanum is related to its origin, place of production, processing methods, ways of administration and patients' condition. Therefore, the clinical use of Zanthoxylum bungeanum involves using different methods and distinguishing the syndrome of patients.

Key words: Zanthoxylum bungeanum, herbal textual research, toxicity of Chinese materia medica, ancient books of maten medica