Chronic Phenotypes of Drug-induced Liver Injury Based on Clinical Cohort

doi:10.19803/j.1672-8629.2021.11.03

Abstract

Abstract: Objectiv eTo evaluate and analyze different clinical phenotypes and characteristics of chronic drug-induced liver injury (DILI). Methods The clinical data on 1 656 patients with DILI who met the inclusion criteria was retrospectively analyzed, and the clinical phenotypes and characteristics of 286 patients with chronic DILI were evaluated. Results The ratio of males to females was 1∶1.92, and the median age was 49.03 yrs. According to the dynamic changes of liver function and development of the disease, chronic DILI could be divided into the persistent type (n=159, 55.6%), recurrent type (n=31, 10.8%), slow recovery type (n=27, 9.4%), and first onset cirrhosis type (n=69, 24.1%). 204 of these cases were able to provide detailed information about medication. 97.7% of the cases of the first onset cirrhosis type were caused by two or more drugs, and the proportion was significantly higher than that of other types (P=0.015). Compared with other types, the MELD score of the first onset cirrhosis type was higher while the prognosis was worse (P<0.05). Conclusion The chronic process of DILI can be divided into four types, the main clinical phenotype of DILI is the persistent type, and the prognosis of the first onset of DILI of the cirrhosis type is poor, which deserves attention in clinic.

Key words: drug-induced liver injury, chronicity, clinical phenotype, retrospective cohort

CLC Number:

R994.11

XU Wentao, WANG Ruilin, BAI Zhaofang, GUO Yuming, ZHANG Fan, WANG Jiabo, NIU Ming, ZOU Zhengsheng, XIAO Xiaohe, JING Jing. Chronic Phenotypes of Drug-induced Liver Injury Based on Clinical Cohort[J]. Chinese Journal of Pharmacovigilance, 2021, 18(11): 1009-1013.

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