Chinese Journal of Pharmacovigilance ›› 2016, Vol. 13 ›› Issue (2): 98-102.

• Orignal Article • Previous Articles     Next Articles

Literature Analysis of 82 Cases of Adverse Drug Reactions Induced by Gefitinib

XIA Hui-hong   

  1. Liaoning Chaoyang Central Hospital, Liaoning Chaoyang 100020, China
  • Received:2016-03-14 Revised:2016-03-14 Online:2016-02-08 Published:2016-03-14

Abstract: ObjectiveTo investigate the characteristics and mechanism of adverse reactions induced by gefitinib, and to find its risk factors and provide technical support for safe and rational use of the drugs in clinic. Methods“Gefitinib”, “adverse reaction” and “caused by” were used as key words to retrieve articles in CNKI and VIP database. 57 literatures which met the inclusion and exclusion criteria were extracted and analyzed. ResultsThere were 82 cases of ADR in literatures, which mainly involved the gastrointestinal system, skin and appendages, respiratory system. Diarrhea, acne-like rash, cough, interstitial pneumonia were most common and some cases were serious even to death. The majority cases were senile male patients. ConclusionIt is important to pay attention to the adverse reactions caused by gefitinib, especially to strengthen post-marketing surveillance for elderly lung cancer patients, so as to prevent severe and rare adverse drug reactions.

Key words: gefitinib, adverse drug reaction, literature analysis

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