Changes of Serum Myocardial Enzyme Spectrum and Prognosis in Elderly Patients with Acute Myocarditis Treated by Trimetazidine

Abstract

Abstract: Objective To observe the change of serum myocardial enzyme in patients with senile viral myocarditis (VM) treated by trimetazidine, and analyze its effect on the prognosis, so as to provide reference for clinical diagnosis and treatment of VM. Methods 114 cases of elderly patients with VM were randomly divided into observation group and control group, 57 cases for each group. All patients were treated with conventional treatment, while trimetazidine 20 mg, tid, was added to the patients in observation group for 6 weeks. In the same period, 50 cases of healthy people were selected to normal group for reference. Then the levels of serum myocardial enzymes and the LVEF were compared between all groups, and the levels of serum myocardial enzymes and the change of LVEF were observed 1, 2, 3, 4, 5, 6 weeks after treatment to investigate the effect of trimetazidine on the serum myocardial enzymes. Results The levels of CK and CK-MB of VM patients were higher than normal group, and the differences were statistically significant (P <0.05). The levels of CK, CK-MB of control group and observation group were significantly decreased, but the changes in observation group were more obvious, the differences were statistically significant (P <0.05). The total effective rate of control group was lower than observation group (84.2% vs 96.5%), the difference was statistically significant (P <0.05). The 1 year survival rate was 93.0% (53/57) in control group,and 98.2% (56/57) in observation group, the difference was not statistically significant (P >0.05). The results of Pearson correlation analysis showed that the CK (r= -0.780) and CK-MB (r=-0.801) had negative correlation with LVEF (P<0.05), while CK (r= -0.791) and CK-MB (r= -0.764) were negatively correlated with 1-year survival (P<0.05). Conclusion Trimetazidine has positive significance to improve the prognosis of elderly patients with VM, and can help to predict the 1-year survival and the change of LVEF combining detection of serum myocardial enzymes.

Key words: elderly, viral myocarditis, trimetazidine, myocardial enzyme spectrum, prognosis

CLC Number:

R972

SUN, Yu-sheng. Changes of Serum Myocardial Enzyme Spectrum and Prognosis in Elderly Patients with Acute Myocarditis Treated by Trimetazidine[J]. Chinese Journal of Pharmacovigilance, 2016, 13(8): 456-459.

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