One case of agranulocytosis induced by methimazole tablets

doi:10.19803/j.1672-8629.2022.03.27

Abstract

Abstract: Objective To explore the possible mechanism of methimazole-induced agranulocytosis (MIA) and treatments for elderly patients. Methods The process of treating one case of an elderly patient with MIA and infection was analyzed based on literature retrieval. Results Despite anti-infection treatments and increasing the number of white blood cells, the patient remained feverish. Then, the patient's granulocytes gradually increased after antibacterial drugs were discontinued and methylprednisolone sodium succinate was supplemented for 3 days. The blood routine of the patient returned to normal on the 17th day. Conclusion The mechanism of MIA includes immune responses, drug toxicity and genetic susceptibility. It is recommended that an individualized dosing plan be made during the diagnosis and treatment of elderly patients.

Key words: methimazole, agranulocytosis, elderly patient

CLC Number:

R994.11

ZHU Yuting, LI Maoxing. One case of agranulocytosis induced by methimazole tablets[J]. Chinese Journal of Pharmacovigilance, 2022, 19(3): 345-348.

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