Literature Analysis of 437 Cases of Adverse Drug Reactions/Events Induced by ATP

Abstract

Abstract: ObjectiveTo probe into the characteristics and influencing factors of ADR cases induced by adenosine triphosphate (ATP), so as to provide a reference for clinical treatment. MethodsBy retrieving published ADR cases caused by ATP in the Chinese Journal Full-text Database between 1975 and 2015, 30 valid documents were obtained, 437 literatures were screened and analyzed retrospectively. ResultsThe main ADR manifestations were chest distress, flushing, dyspnea, headache, arrhythmia, nausea, limb numbness, etc. ConclusionThe ADRs of intravenous administration and non intravenous administration were different, the occurrence of adverse reactions may be related to the drug dosage, the clinical use dose of ATP is not unified, there are many differences in the method of administration between home and abroad.

Key words: adenosine triphosphate (ATP), adverse drug reaction (ADR), literature analysis

CLC Number:

R994.11
R972

YUAN Xing-dong, XU Jin, ZHONG Chang-ming, ZHOU Juan, XU Yu-ming. Literature Analysis of 437 Cases of Adverse Drug Reactions/Events Induced by ATP[J]. Chinese Journal of Pharmacovigilance, 2016, 13(2): 94-97.

References

[1] 王翔朴,王营通,李珏声.卫生学大辞典[M].青岛:青岛出版社, 2000:608-609.
[2] 聂云.小剂量三磷酸腺苷快速静脉注射终止阵发性室上性心动过速的效果观察[J].实用心脑肺血管病杂志, 2013,21(7):74-75.
[3] 刘锡昌,田普永. 三磷酸腺苷钠引起变态反应一例报告[J]. 西北国防医学杂志, 1995,6(4):388.
[4] 周菊明,吴维生.三磷酸腺苷严重过敏反应2例[J].广东医学, 2005, 26(7):909.
[5] 齐冬颖,武玉红.三磷酸腺苷、辅酶A合用不良反应一例[J].传染病信息, 1998,11(4):175.
[6] 丁国华.三磷酸腺苷的不良反应[J].实用医技杂志,1997,4(7):528-829.
[7] 欧阳荔莎,马爱平,张立红.三磷酸腺苷致过敏反应1例药物[J].流行病学杂志, 2001,10(3):166-167.
[8] 钱思兰.三磷酸腺苷致过敏反应一例报告[J].实用临床医学,2008,9(7):3.
[9] 尤华王,维中苏,荣华. ATP静脉注射的严重不良反应[J].临床荟萃, 1995,10(17):815-816.
[10] 杜军.三磷酸腺苷致心律失常作用及对策[J].临床荟萃,1995,10(20):918.
[11] 李德芹.三磷酸腺苷致过敏反应1例[J].潍坊医学院学报,1997,19(2):96.
[12] 阎慧芳.肌注ATP致玫瑰糠样药疹1例[J].临床皮肤科杂志,1989,18(4):218.
[13] 殷继云,李爱香.静脉滴注三磷酸腺苷致过敏反应一例[J].中原医刊, 2002,29(1):61.
[14] 毕展文.ATP致心脏骤停3例[J].临床荟萃,1995,10(22):1053-1054.
[15] 凌文革,陈子儒.静滴ATP致严重不良反应4例[J].广东医学院学报, 1995,13(2):161.
[16] 周锡晶.静脉注射ATP的副作用及处理[J].临床内科杂志,1990,7(4):42.
[17] 刘奉朝,喻桂玲,董霞,等.静脉注射ATP致不良反应11例[J].河北医药, 1990,12(6):364.
[18] 闰春雷,闰英旺.静脉注射ATP终止室上性心动过速致心脏骤停1例[J].河北医药, 1997,19(2):128
[19] 谷光第.静脉注射三磷酸腺普引起不良反应6例报告[J].辽宁医学杂志, 1989,3(2):82.
[20] 喻桂玲,张金彪.老年肺心病患者静注ATP的不良反应4例报告[J].中华老年医学杂志, 1990,9(3):154.
[21] 曾玉琼.静滴ATP合剂诱发哮喘大发作1例[J].重庆医学,1997,26(6):375.
[22] 王尚兰.静注三磷酸腺苷(ATP)致心脏骤停一例报告[J].青海医药杂志, 2009,39(6):66.
[23] 朱晓光.静滴ATP致严重过敏反应1例[J].临床荟萃,1995,10(22):1054.
[24] 黄承忠.静注ATP致死一例[J].湖南医学, 1990,7(2):120.
[25] 戴学清,吴佳滨,胡甜.三磷酸腺苷的严重不良反应[J].中国药业, 1998,7(7):44-45.
[26] 唐中坤.三磷酸腺苷二钠注射液代替腺苷转复室上性心动过速临床分析[J].中国社区医师, 2012,14(319):79.
[27] 胡翠芝,李旭.三磷酸腺苷致严重心律失常和过敏反应[J].人民军医, 1999,42(9):532-533.
[28] 邱林林,刘学庆,郜黎伟,等.静脉快速注射 ATP 终止阵发性室上性心动过速的效果与安全性观察[J].交通医学, 2008,22
(2):143-144.
[29] 陈玉萍.ATP诱发梗塞后心绞痛发作1例[J]山东医药, 1992,32(11):61.
[30] 姜建党,石红敏.三磷酸腺苷终止阵发性室上速的疗效观察[J].中国社区医师, 2010,12(245):31.
[31] 刘丽丽,三磷酸腺苷注射液引起的不良反应[J].中国药业,1999,8(7):58-59.
[32] 井来敏.三磷酸腺苷二钠(ATP)诱发心绞痛1例报告[J].天津药学, 1996,8(1):43.
[33] 许存兰,张绍广.ATP致游走性浅静脉炎1例报告[J].青海医药杂志, 1997,27(1):11.
[34] 张铭.三磷腺苷治疗阵发性房室结或房室折返性心动过速51例[J].中国实用医药, 2011,6 (16):155-156.
[35] 马云霞.ATP引起窦缓及心跳骤停1例报告[J].宁夏医学杂志,1996,18(6):355.
[36] 孙普军.静注三磷酸腺苷致严重不良反应一例报告[J].四川医学, 1988,9(2):106.
[37] 孙理社.普罗帕酮与三磷酸腺苷治疗阵发性室上性心动过速的疗效观察[J].中国实用医药, 2012,7(17):183-184.
[38] 彭超敏,孙振锁.静注ATP致死4例[J].中级医刊,1995,30(8):44.
[39] 任振祥,李爱民.静脉注射胺碘酮、三磷酸腺苷致心脏骤停一例[J].中国循环杂志, 1995,11(2):121.
[40] 黄承惠.静注ATP致死一例[J].湖南医学, 1990,7(2):120.
[41] Zimmermann H.5’-Nucleotidase:Molecular structure andfunctional aspects[J].Biochem J. 1992,285(Pt2):345.
[42] 国家药典委员会.临床用药须知 [M]. 2010版,北京:中国医药科技出版社, 2011:296-297.
[43] Sweetman S C.Martindale 35:The Complete Drug Reference[M].35 th edition, London UK:Pharmaceutical Press,2011:742-743.
[44] 颜黎新.三磷酸腺苷治疗15例室上性心动过速的临床分析[J].中外医疗, 2009,28:31.
[45] 李东柏.陈发性室上性心动过速的急诊治疗现状[J].河北医药, 2007,29(3):255-257.
[46] Lerman B B, Beladinelli L. Cardiac electrophysiology ofadenosine. Basic and clinical concepts[J]. Circulation, 1991,83(5):1499-1509.
[47] Pelleg A,Hurt C,Michelson L,et al.Differential sensi-tivity of cardiac pacemakers to exogenous adenosine in vivo[J].Am J Physiol, 1990,
258(6 Pt 2):1815-1822.
[48] Reed R,Falk J L.Untoward reaction to adenosine thera-py for supraventricular tachycardia[J].Am J Emerg Med,1991,9(10):566-570.
[49] Brodsky M A,Hwang C.Life-threatening alterations inheart rate after the use of adenosine in atrial fluter[J].AmHeart J, 1995,130(3 Pt 1):
564-571.
[50] Sabrina L,Wilbur M D,Francis E. Adenosine as an an-tiarrhythmic agent[J].Am J Cardiol, 1997,79(79):30-37.