Abstract: Objective To study the risk factors and precautions for adverse drug reactions(ADR) caused by digoxin so as to ensure safe and rational use of this drug. Methods Based on related literature, digoxin-related ADR, risk factors, precautions, digoxin poisoning monitoring and treatments were reviewed. Results ADR caused by digoxin were similar to the first symptoms of the disease. Age, gender, drug interactions, liver and kidney function, timing of blood collection, genetic factors, dosage, administration compliance, and other variables were among the wide range of risk factors for ADR. Toxic reactions were severe once they occurred. Conclusion The risk factors should be avoided to the great extent possible during administration. Patients should be given proper administrations in order to minimize intoxication reactions and other ADR.

Key words: digoxin, adverse drug reaction, cardiac glycosides, precaution, heart failure, risk factors, intoxication