Adverse reactions caused by levetiracetam

doi:10.19803/j.1672-8629.20220719

Abstract

Abstract: Objective To analyze the occurrence and clinical characteristics of adverse drug reactions (ADR) induced by levetiracetam and to promote rational clinical drug use. Methods Case reports about ADR induced by levetiracetam in Chinese and English databases between January 1, 1999 and November 1, 2022 were collected and analyzed. Results A total of 77 articles about ADR caused by levetiracetam were retrieved and 85 patients (37 men and 48 women) were included. ADR mainly occurred within 30 days (63.53%) of therapy. The top three adverse drug reactions were respectively mental disorders (28.42%), skin and its appendage damage (17.89%) and blood and lymphatic system abnormalities (13.68%). Conclusion Levetiracetam can cause some new and serious ADR. It is necessary to raise the awareness of ADR caused by levetiracetam while medication should be monitored more rigorously to ensure the safety and efficacy of drug use.

Key words: levetiracetam, mental disorders, skin and its appendage damage, blood and lymphatic system abnormalities, adverse drug reaction

CLC Number:

R971.6
R994

LIANG Dong, LUO Li, CHENG Junxiang. Adverse reactions caused by levetiracetam[J]. Chinese Journal of Pharmacovigilance, 2023, 20(9): 1054-1059.

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