Abstract: Objective To provide reference for safe use of β-lactam in hemodialysis patients. Methods A case of mental abnormality caused by piperacillin sodium and sulbactam sodium for injection in a regular hemodialysis patient was retrospectively analyzed to find out about the possible causes of adverse drug reactions and the safety of medication. Results The adverse drug reactions might have involved piperacillin sodium and sulbactam sodium for injection. After drug withdrawal and symptomatic treatment, the patient developed no more mental abnormalities. Conclusion The dose or interval of piperacillin sodium and sulbactam sodium for injection should be adjusted according to the endogenous creatinine clearance(Ccr) to ensure the safety and efficacy of medications. Clinicians should be alert to serious adverse reactions related to the central nervous system.

Key words: piperacillin sodium and sulbactam sodium, adverse drug reaction, uremia, mental disorder, hemodialysis