Abstract: Objective To explore neuro-related adverse reactions of lenalidomide in elderly patients with advanced tumors. Methods One case of neuro-related adverse reactions that resembled epileptic-like seizures shortly after the administration of lenalidomide 10 mg in an elderly patient with advanced tumors was analyzed by referring to literature. Results After taking lenalidomide 10 mg, the patient presented with convulsion like transient seizures with urinary incontinence and unconsciousness, which were gradually alleviated on their own after one to two minutes, and no more CNS symptoms occurred after discontinuation of lenalidomide. More than twenty days later, the patient resumed 10 mg of lenalidomide and experienced transient loss of consciousness with convulsions a second time, but the symptoms were improved after withdrawal. Conclusion Lenalidomide is a new drug for the treatment of refractory recurrent lymphoma in recent years. Clinicians should be alert to the adverse reactions of the drug involving the central nervous system when prescribing it to elderly patients with advanced tumors.

Key words: lenalidomide, lymphoma, central nervous system, epileptic, adverse drug reaction