Pharmaceutical care of a severely poisoned patient with methotrexate tablets

doi:10.19803/j.1672-8629.2022.08.23

Abstract

Abstract: Objective To explore the effective medication plan for a patient with severe methotrexate poisoning. Methods Clinical pharmacists participated in the treatment of a patient with severe methotrexate poisoning. By analyzing the common adverse reactions and pharmacokinetic characteristics of antibiotics and based on bacterial culture and related examination indexes, clinical pharmacists recommended quickly adjusting the antibacterial treatment plan. Given the individual factors of the patient, clinical pharmacists advised the clinicians to adopt the bone marrow suppression detoxification scheme as soon as possible. According to the coagulation function, biochemical indexes and pharmacological characteristics of related drugs, the clinical pharmacists gave tips on ways of appropriate hemostasis, acid suppression, and fluid replacement. Results After hospitalization, the patient was out of danger, the overall outcome was good, and she was discharged. Conclusion Clinical pharmacists can assist clinicians in adjusting the drug regimen and improve the level of clinical medication by making full use of their knowledge of pharmaceuticals.

Key words: methotrexate poisoning, clinical pharmacist, treatment programs, drug therapy, adverse drug reaction

CLC Number:

R915
994.11

YUAN Xiaolong, WAN Qihua, TAO Donghong, QI Hao, WANG Aixia. Pharmaceutical care of a severely poisoned patient with methotrexate tablets[J]. Chinese Journal of Pharmacovigilance, 2022, 19(8): 924-928.

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