Thirty-six cases of adverse drug reactions/events caused by Xinhuang tablets

doi:10.19803/j.1672-8629.2022.05.19

Abstract

Abstract: Objective To retrospectively analyze ADR induced by Xinhuang tablets in order to provide reference for rational use of this drug in clinic.Methods?With?"Xinhuang tablets",?"adverse reaction" or "cause" as the key words, related articles were retrieved from the CNKI, Wanfang database and VIP Chinese full-text database that had been published from the inception to April 30, 2020. Literature related to ADR induced by Xinhuang tablets was screened and analyzed.?Results?Twenty-four articles were included, involving 36 cases of adverse drug reactions. The dominating adverse reactions were manifested as neurological damage, gastrointestinal damage and systemic damage. Common symptoms included nausea, vomiting, dizziness, headache and chest distress. Anaphylactic shock, which was life threatening, was also reported in severe cases. Conclusion It is important that clinicians and patients become aware of ADR induced by Xinhuang tablets. Precaution should be taken to ensure the safe use of this drug.

Key words: Xinhuang tablets, adverse drug reaction, literature review, Chinese patent medicine

CLC Number:

R994.11

ZHANG Ruili, SU Shuang, JIANG Jiming, ZHANG Jing. Thirty-six cases of adverse drug reactions/events caused by Xinhuang tablets[J]. Chinese Journal of Pharmacovigilance, 2022, 19(5): 561-563.

References

[1] Chinese Pharmacopoeia Commission.Chinese Pharmacopeia Guidelines for Clinical Drug Use of TCM Prescription Preparation Volume(中华人民共和国药典临床用药须知:中药成方制剂卷)[M]. 2015 ed. Beijing: China Medical Science and Technology Press, 2017: 951.
[2] CHEN JZ, XU YQ, TANG Z, et al.Acute renal injury and leukopenia induced by acyclovir combined with Xinhuang tablets: a case report[J]. Chinese Journal of Pharmacoepidemiology(药物流行病学杂志), 2019, 28(12): 836-838.
[3] MAI MJ, WANG F.A case of anaphylactic shock caused by oral compound Aminopyrine tablets and Xinhuang tablets[J]. Xinjiang Journal of Traditional Chinese Medicine(新疆中医药), 2002, 20(1): 28.
[4] CHEN LH, WANG DJ.A case of stomach noise and tongue ulcer caused by Niuhuangjiedu tablet and Xinhuang tablet[J]. Seek Medical and Ask The Medicine(求医问药), 2012, 10(9): 280.
[5] LIN YM.6 cases of drug-induced gastric bleeding caused by Xinhuang tablets[J]. World Chinese Journal of Digestion(华人消化杂志), 1998, 6(S2): 390.
[6] PAN J.A case of drowsiness caused by Xinhuang tablet[J]. Journal of Navy Medicine(海军医学杂志), 2013, 34(4): 261.
[7] SUN YY.The nursing experience of a case of oral Xinhuang tablets caused allergic asthma[J]. Chinese Journal of Modern Drug Application(中国现代药物应用), 2015, 9(18): 186-187.
[8] ZHANG H, MAO WZ.A case report of asphyxia-like asthma caused by oral administration of Xinhuang tablets[J]. Fujian Journal of Traditional Chinese Medicine(福建中医药), 1997, 28(2): 48.
[9] CHEN DH.A case report of angioedema caused by Xinhuang tablet[J]. Chinese Practical Journal of Rural Doctor(中国实用乡村医生杂志), 2005, 12(8): 50.
[10] GUO JH.A case of anaphylactic shock caused by taking Xinhuang tablets on an empty stomach[J]. Journal of Handan Medical College(邯郸医学高等专科学校学报), 2001, 14(2): 116-117.
[11] HU QQ.Nursing care of a patient whose body temperature does not rise due to Xinhuang tablets[J]. Chinese Nursing Research(护理研究), 2011, 25(30): 2819-2820.
[12] PU YJ, ZHAO YJ, WU FB, et al.Literature analysis of 137 ADR induced by indometacin oral preparation[J]. China Pharmacy(中国药房), 2010, 21(36): 3435-3436.
[13] LIU J, DI ZQ, WANG JJ, et al.Mechanism of Chinese herbal ingredients in Xinhuang tablet on attenuating gastrointestinal toxicity induced by indomethacin[J]. Chinese Traditional and Herbal Drugs(中草药), 2014, 45(8): 1115-1120.
[14] CHEN XQ, JIN YY, TANG G.New edition of Pharmacology(新编药物学)[M]. Beijing: People's Medical Publishing House, 2011: 186-187.
[15] WANG LJ, XIE TY.3 cases of anaphylactic shock caused by Zhongjiefeng injection[J]. Medical Journal of Chinese People's Health(中国民康医学), 2007, 19(3): 235.
[16] YUAN XJ, LI PL.A case of anaphylactic shock caused by indomethacin[J]. People's Military Surgeon, 2016, 59(9): 899.
[17] XIE WY.2 cases of allergic reactions caused by Xinhuang tablets[J]. Journal of Practical Traditional Chinese Medicine(实用中医药杂志), 2002, 18(1): 54.
[18] LIN Z.2 cases of allergic asthma caused by Xinhuang tablets[J]. Chinese Journal of Coal Industry Medicine(中国煤炭工业医学杂志), 2005, 8(7): 679.
[19] LIN WM.4 cases of reactions by oral administration of Xinhuang tablets[J]. Fujian Journal of Traditional Chinese Medicine(福建中医药), 1984(3):39.
[20] BIAN BY, SHAO R, CHEN YF, et al.Meta-analysis of the indications of Xinhuang tablets[J]. China Journal of Pharmaceutical Economics(中国药物经济学), 2007, 15(4): 37-42.
[21] LU HS, GAN JB, CHEN ZY, et al.Clinical application of Xinhuang tablets in dermatology[J]. Zhejiang Journal of Integrated Traditional Chinese and Western Medicine(浙江中西医结合杂志), 2015, 25(1): 102-104.