Abstract: Objective To investigate the mechanism of blurred vision induced by atropine combined with penehyclidine hydrochloride. Methods The process of diagnosing and treating a patient with blurred vision caused by atropine and penehyclidine hydrochloride during general anesthesia was analyzed while the mechanism by which long-term blurred vision was caused by atropine combined with penehyclidine hydrochloride was investigated based on literature analysis. Results The patient had blurred vision postoperatively, but no obvious abnormality was found after eye examination, so no special treatment was given. The patient recovered spontaneously after 2 weeks. Conclusion The long-term blurred vision caused by atropine combined with penehyclidine hydrochloride is related to the fact that both of them are anticholine drugs. To prevent adverse reactions, drugs of the same type should not be used in combination. When the combination is absolutely necessary, it is critical to prevent the synergy of two drugs and reduce the dosage.

Key words: atropine, penehyclidine hydrochloride, blurred vision, general anesthesia, adverse drug reaction