Abstract: Objective To standardize the prevention and treatment of drug-related anaphylactic shock, so as to ensure the safety and effectiveness of clinical medication. Methods The drug-related anaphylactic shock reports reported by Renji Hospital, Shanghai Jiaotong University School of Medicine through the National Adverse Drug Reaction Monitoring System from January 1, 2009 to December 31, 2019 were collected. The general information, sensitizing drugs, treatment drugs and prognosis of the patients were retrospectively analyzed. Results A total of 62 reports of drug-related anaphylactic shock were included. The sexes of the patients were 56 males and 6 females. The ratio of males to females was 9.33∶1. The ages were mainly distributed over 60 years old (61.29%). The average time of anaphylactic shock was (9.90±11.44) min, and it mainly occurred in the initial stage of medication <10 min (74.2%). In terms of drug treatment, 36 cases (58.06%) were treated with epinephrine, and most (27 cases, 75%) were administered by intravenous bolus injection, followed by intramuscular injection (3 cases, accounting for 8.35%) . In the reports of 27 cases of intravenous bolus injection and 3 cases of intramuscular injection, the single dose was too large. Outcome: cured or improved accounted for 98.38%. Conclusion Anaphylactic shock usually occurs quickly and severely. While paying attention to the prevention of adverse reactions, it is necessary to pay attention to the correct rescue of anaphylactic shock and regulate the use of epinephrine in time to ensure the safety of patients.

Key words: drug-induced anaphylactic shock, epinephrine, adverse drug reaction