Adverse drug reactions of hypokalemia caused by voriconazole in a hospital of Anhui Province

doi:10.19803/j.1672-8629.20210395

Abstract

Abstract: Objective To investigate the adverse reactions of hypokalemia induced by voriconazole and the influencing factors in order to provide reference for safe use in clinic. Methods Based on the Chinese Hospital Pharmacovigilance System (CHPS), 287 cases of adverse reactions of voriconazole reported in a hospital between Jan 1, 2018 and Dec 31, 2020 were selected for retrospective analysis so as to explore the incidence, clinical characteristics, risk factors and outcomes of adverse reactions of hypokalemia induced by voriconazole. Results Data showed that the incidence of hypokalemia caused by voriconazole was 41.2%(118 cases). There was no significant difference in the incidence of hypokalemia between primary diseases (P>0.05). Within one or two days of administration, the incidence of hypokalemia caused by injection formulations was significantly higher than that of oral formulations(P<0.05). The incidence of severe adverse reactions caused by injection formulations was significantly higher than that of oral formulations (P<0.05). Conclusion The proportion of hypokalemia caused by voriconazole injections is higher than that of oral preparations. These adverse reactions often occur soon after the use of voriconazole, which deserves more attention in clinic.

Key words: voriconazole, hypokalemia, adverse drug reaction

CLC Number:

WANG Lechen, SHEN Aizong. Adverse drug reactions of hypokalemia caused by voriconazole in a hospital of Anhui Province[J]. Chinese Journal of Pharmacovigilance, 2022, 19(11): 1238-1241.

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