Research Progress on Nucleos(t)ide Analogues Resistance Mechanism and Mutation Sites

doi:10.19803/j.1672-8629.2021.08.22

Abstract

Abstract: Nucleos(t)ide analogues (NAs)-resistant hepatitis B is caused by gene mutations in the reverse transcriptase region of hepatitis B virus (HBV) after long-term use of NAs. NAs resistance could lead to treatment failure, and it is also one of the important reasons for liver disease progression. Clarifying the mechanism of HBV NAs resistance is of great help to strategy selection and prognosis treatment; combing the mutation site of HBV NAs resistance will provide the basis for further exploring the risk signals of drug-resistant hepatitis B and clinical precise prevention and control. This review analyzed the molecular mechanism and mutation site of NAs-resistant hepatitis B, hoping to provide a reference for the prevention and treatment of NAs-resistant hepatitis B.

Key words: chronic hepatitis B virus infection, nucleos(t)ide analogues, drug-resistant mutations, molecular mechanism, mutation site, risk signal

CLC Number:

R978.7

LI Yuanhua, GE Feilin, CHEN Rongjuan, BAI Zhaofang, LI Le, ZHAO Jing, LIU Yan, LIU Wenlong, XIAO Xiaohe. Research Progress on Nucleos(t)ide Analogues Resistance Mechanism and Mutation Sites[J]. Chinese Journal of Pharmacovigilance, 2021, 18(8): 795-799.

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