The research on Mechanism and Risk Warning of Melanosis Coli Caused by Emodin

doi:10.19803/j.1672-8629.2021.08.11

Abstract

Abstract: Objective To explore the mechanism by which emodin inhibits macrophage activation, explain its role in the occurrence of melanosis coli, and find out about the potential risk of emodin induced melanosis coli. Methods Bioinformatics technology was used to screen and analyze the gene chips GSE 73309 and GSE 73310 related to inhibition of macrophage activation by emodin in GEO database. Gene Ontology(GO) annotation, Kyoto Encyclopedia of Genes Genomes (KEGG) pathway analysis, and Protein-protein interaction network analysis were performed on differentially expressed genes. By retrieving literature on clinical applications and basic research of emodin, the biological basis of rhubarb-induced melanosis coli was explored, and the results of biological information analysis were mutually confirmed. Results The biological pathways through which emodin inhibited macrophage activation were mainly manifested in inflammatory responses and cancer pathways related to tumor necrosis factors (TNF) and hypoxia inducible factors (HIF). Conclusion The mechanism by which emodin induces melanosis coli is closely related to the inflammatory reaction induced by emodin. In addition, emodin can potentially induce breast cancer, ovarian cancer and lung airway inflammation.

Key words: emodin, melanosis coli, anthraquinone traditional Chinese medicine, risk warning

CLC Number:

R932 R994.13

HUANG Zhengkai, LIN Zhijian, WANG Yu, GUO Fanfan, ZHANG Bing. The research on Mechanism and Risk Warning of Melanosis Coli Caused by Emodin[J]. Chinese Journal of Pharmacovigilance, 2021, 18(8): 753-759.

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