中国药物警戒 ›› 2021, Vol. 18 ›› Issue (9): 876-879.
DOI: 10.19803/j.1672-8629.2021.09.17

• 安全与合理用药 • 上一篇    下一篇

基于医院信息系统真实世界生脉注射液临床用药特征分析

姚亚敏1, 姚迪1, 陈燕秋2, 刘力1,*   

  1. 1上海中医药大学附属曙光医院,上海200120;
    2上海和黄药业有限公司,上海201401
  • 收稿日期:2021-01-07 出版日期:2021-09-15 发布日期:2021-09-18
  • 通讯作者: *刘力,女,主任药师,教授,中药临床药学。E-mail:liuli2750@163.com
  • 作者简介:姚亚敏,女,主管药师,临床药学。
  • 基金资助:
    上海市科学技术委员会科研项目（16DZ1920100）

Clinical Characteristics of Shengmai Injection Based on the Hospital Information System in the Real World

YAO Yamin1, YAO Di1, CHEN Yanqiu2, LIU Li1,*   

  1. 1Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200120, China;
    2Shanghai Hutchison Pharmaceuticals, Shanghai 201401, China
  • Received:2021-01-07 Online:2021-09-15 Published:2021-09-18

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摘要： 目的 了解真实世界中生脉注射液的临床应用特征,为规范其临床应用提供参考。方法 基于医院信息系统,收集医院2017年10月1日~ 2019年5月31日使用生脉注射液治疗的1 014例住院病例,对患者的一般资料及其诊断、临床用药、合并用药和药品不良反应进行统计分析,并利用Apriori算法进行合并用药关联分析。结果 1 014例使用生脉注射液的患者中男性560例（55.23%）,女性454例（44.77%）,平均年龄62.67岁。主要分布在内分泌科、急诊科和神经内科;西医诊断多用于糖尿病（463例,45.56%）,中医诊断多用于消渴病（446例,43.98%）证型主要为气阴两虚证（450例,44.38%）。给药途径主要为静脉滴注给药,单次剂量集中在20~60 mL（96.81%）,用药疗程集中在1~14 d（97.69%）,平均5.7 d。最常与生脉注射液合并应用的药品依次为胰岛素注射液、二甲双胍片和阿托伐他汀钙片。结论 生脉注射液临床应用更符合中医辨证论治的特点,用法用量基本符合说明书的要求,联合用药较为合理,但仍存在超说明书用药的问题,临床医生应规范其临床应用,保证用药安全。

关键词: 生脉注射液, 真实世界研究, 用药特征

Abstract: Objective To study the characteristics of clinical use of Shengmai Injection in the real world, and to provide reference for standardizing its clinical use. Methods Based on the hospital information system, 1014 cases of inpatients who received Shengmai Injection between October 1, 2017 and May 31, 2019 were selected and their basic information, diagnostic data, clinical drug use, drug combinations and adverse drug reactions were analyzed with statistical software before association analysis of combined medications was performed by the Apriori algorithm. Results 560 of these cases were male (55.23%), 454 were female (44.77%), and the average age was 62.67 years old. Most of them were treated in Departments of Endocrinology, Emergency and Neurology. Shengmai Injection was mainly used for diabetes mellitus in western medicine, but for Xiao Ke disease(446 cases,43.98%)with syndromes of both Qi -Yin deficiency(450 cases,44.38%) in TCM. All the patients were administered by intravenous drip with a single dose of 20-60ml (96.8%). The course of treatment usually lasted 1-14 days (97.69%) with an average of 5.7 days. The drugs most commonly used in combination with Shengmai Injection were insulin injection, metformin tablets and atorvastatin calcium tablets. Conclusion The clinical use of Shengmai Injection conforms to theories of TCM. The usage and dosage basically follow drug instructions and the combination of drugs is relatively well-grounded. However, off-label use can be found so that doctors should standardize drug use and ensure the safety of medication.

Key words: Shengmai injection, real-world study, characteristics medication

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