中国药物警戒 ›› 2022, Vol. 19 ›› Issue (1): 36-40.
DOI: 10.19803/j.1672-8629.2022.01.08

• 真实世界老年/儿童患者应用中成药的现状研究专栏 • 上一篇    下一篇

真实世界生脉注射液治疗9215例老年心血管疾病的临床特征及联合用药研究

孙春全1, 谢雁鸣1,*, 侯恒悦2   

  1. 1中国中医科学院,中医临床基础医学研究所,北京 100700;
    2中国人民大学统计学院,北京 100872
  • 收稿日期:2021-02-26 出版日期:2022-01-15 发布日期:2022-01-20
  • 通讯作者: *谢雁鸣,首席研究员,博导,中药上市后评价研究及老年病。E-mail：ktzu2018@163.com
  • 作者简介:孙春全,男,博士,老年病。
  • 基金资助:
    国家重点研发计划（2018YFC1707400）

Clinical characteristics and combined medication of Shengmai injection in the treatment of 9215 elderly patients with cardiovascular diseases

SUN Chunquan1, XIE Yanming1,*, HOU Hengyue2   

  1. 1Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China;
    2School of Statistics, Renmin University of China, Beijing 100872, China
  • Received:2021-02-26 Online:2022-01-15 Published:2022-01-20

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摘要： 目的 为深入研究真实世界中生脉注射液（SMI）治疗老年心血管疾病的临床特征,以医院信息管理系统（hospital information system, HIS）为基础,进行了生脉注射液的真实世界研究。方法 利用R软件对HIS数据库中2001年1月1日至2016年12月31日29家三甲医院的9 215例老年心血管疾病患者数据进行数据挖掘,分析患者的临床特征、生脉注射液的用药特点。结果 男性患者（5 109例）多于女性（4 035例）,性别不详71例;平均年龄（78.15±6.90）岁,平均住院天数（25.39±19.88）d,高血压、呼吸道感染、心律失常为最常见的合并疾病,主要用药途径为静脉滴注（7 504例）,静脉滴注的单次使用剂量平均（55.79±18.06）mL,平均用药疗程（6.02±7.37）d。最为常用的用药组合包括痰热清注射液+氨溴索等。结论 通过对HIS数据库老年心血管疾病的挖掘分析,可初步掌握患者的基本特征、生脉注射液的用药特征,为指导临床医生合理联合应用生脉注射液提供参考。

关键词: 真实世界, 生脉注射液, 老年心血管疾病, 医院信息管理系统, 临床特征

Abstract: Objective To conduct a real-world study of Shengmai injection based on the hospital information system (HIS) in order to find out more about the clinical characteristics of elderly patients with cardiovascular diseases who use Shengmai injection (SMI). Methods The clinical data on 9 215 elderly patients with cardiovascular diseases treated in 29 tertiary hospitals between January 1, 2001 and December 31, 2016 was retrieved from the HIS database by R software to analyze the clinical characteristics of patients and ways in which Shengmai injection was used. Results There were 5 109 male patients and 4 035 female ones involved. The average age of these patients was (78.15±6.90) years, and their length of hospital stay averaged (25.39±19.88) days. Hypertension, respiratory tract infection and arrhythmia were the most common comorbidities. The main route of administration of SMI was intravenous drip (7 504 cases) and the average single dose was (55.79±18.06) ml. The average duration of treatment was (6.02±7.37) days. The most commonly used drug combinations included Tanreqing injection+ambroxol. Conclusion Analysis of the data on elderly patients with cardiovascular diseases has revealed some of the characteristics of these patients and ways of medication of SMI, which can help clinicians to use SMI rationally.

Key words: real world, Shengmai injection, cardiovascular diseases in the elderly, hospital information system, clinical characteristics

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