益母草毒性研究进展

中国药物警戒 ›› 2014, Vol. 11 ›› Issue (2): 70-73.

益母草毒性研究进展

孙蓉¹, 冯群², 赵庆华³, 李晓宇¹, 赵红⁴

1山东省中医药研究院,山东济南,250014;
2天津中医药大学,天津 300073;
3山东中医药大学,山东济南,250355;
4中国人民解放军海军总医院,北京 100048

收稿日期:2013-01-31 修回日期:2016-02-03 出版日期:2014-02-08 发布日期:2016-02-03
作者简介:孙蓉,女,研究员,博士生导师,中药药理与毒理研究。
基金资助:
基金项目：国家中医药管理局中医药科学技术研究专项“有毒中药”质量控制及有毒成分限量示范研究（2004ZX00）

Advances in Studies on Toxicity of Herba Leonuri

SUN Rong¹, FENG Qun², ZHAO Qing-hua³, LI Xiao-yu¹, ZHAO Hong⁴

1Shandong Academy of Chinese Medicine, Shandong Ji'nan 250014, China；
2Tianjin University of Traditional Chinese Medicine, Tianjin 300073, China；
3Shandong University of Traditional Chinese Medicine, Shandong Ji'nan 250355, China；
4PLA Navy General Hospital, Beijing 100048, China

Received:2013-01-31 Revised:2016-02-03 Online:2014-02-08 Published:2016-02-03

摘要/Abstract

摘要： 目的明确益母草毒性特点、毒性物质基础和毒性作用机制,探讨药物功效与毒性相关性,为今后安全标准制订和进行功效物质基础下益母草的毒性研究提供文献依据和研究思路。方法对近十几年来益母草相关文献进行整理、归纳与分析。结果常用中药益母草具有活血调经、利尿消肿的功效,是传统的妇科圣药。但关于益母草及含益母草的中成药的不良反应有大量文献报道,现代毒理学实验亦表明益母草有毒性,并初步探讨了其毒性产生剂量、物质基础、作用部位及其产生机制。结论应在益母草功效表达和功效物质基础分离与控制的过程中,正确认识药物功效、毒性和不良反应之间的关系,提出切合益母草临床使用过程中药品不良反应的预警方案和早期诊疗措施,制定益母草毒性物质基础的安全限度和药效物质基础的含量标准,为临床使用益母草提供安全保障。

关键词: 益母草, 毒性特点, 物质基础, 毒性机制

Abstract: ObjectiveThe toxicity characteristics, chemical material basis and toxic mechanism of Herba Leonuri were determined and the correlation of its efficacy and toxicity were discussed. The literature evidence and research ideas were provided for making safety standards, and studying its toxicity based on its efficacious substance basis. MethodsLiteratures in latest decades at home and abroad about Herba Leonuri were collated, analyzed and summarized. ResultsAs a commonly used traditional Chinese medicine, Herba Leonuri, which has the efficacy of promoting blood flow for regulating menstruation, diuresis and edema was a traditional Chinese medicine. A number of adverse reactions of Herba Leonuri or Chinese patent drugs containing it were reported. Modern toxicology studies have shown that Herba Leonuri had toxicity, and the dose range, substance basis, site of action and damage mechanism were discussed by toxicology experiment. ConclusionThe Herba Leonuri toxicity and controlling of toxic material basis are studied during the expression of effectiveness and the separation and quality controlling of efficacious material basis, the relationship between the drug efficacy, toxicity and adverse reactions are determined. And we can put forward early-warning scheme and treatment measures of adverse reaction in clinical usage. The safety limitation and standard of content of material basis from Herba Leonuri are established to ensure the safe use of Herba Leonuri as a clinical drug.

Key words: Herba Leonuri, toxicity characteristics, chemical material basis, toxicity mechanism

中图分类号:

R282

孙蓉, 冯群, 赵庆华, 李晓宇, 赵红. 益母草毒性研究进展[J]. 中国药物警戒, 2014, 11(2): 70-73.

SUN Rong, FENG Qun, ZHAO Qing-hua, LI Xiao-yu, ZHAO Hong. Advances in Studies on Toxicity of Herba Leonuri[J]. Chinese Journal of Pharmacovigilance, 2014, 11(2): 70-73.

参考文献

[1] 国家药典委员会.中华人民共和国药典（一部）[M].北京：中国医药科技出版社,2010：272-273.
[2] LIUXH, XINH,ZHUY Z. More than a "mother-benefiting" herb: cardioprotective effect of Herbal Leonuri[J]. Acta Physiologica Sinica, 2007, 59(5): 578-584.
[3] LI Hua-tao, SU Dong-hai, SHANG Tao, et al. Antioxidant activity of the essential oils and aqueous extracts obtained from five Chinese herbal medicines[J].Nat Prod Res Dev,2008,20(6): 974-982.
[4] 王艳丽.益母草胶囊联合利凡诺治疗在中期引产中的应用研究[J].陕西中医,2013,34(3)：268-269.
[5] 张友志,彭勇.中药益母草致过敏反应1例[J].湖北中医杂志,2012,34(10)：61.
[6] 吕丽姝.益母草在阴道分娩过程中预防产后出血的临床观察[J].中国实用医药,2011,6(9)：157-158.
[7] 程薇,周新娥,隆玉华,等.益母草注射液用于预防选择性剖宫产术后出血初探[J].四川生理科学杂志,2010,32(3)：120-122.
[8] 崔张新,尚金星,雷慧,等.益母草文献考证[J].现代中西医结合杂志2010,19(5)：627-630.
[9] 孙玉琦,马永刚,邢小燕,等.论中药不良反应的客观真实性[J].中国中药杂志,2006,31(16)：1381-1383.
[10] 李万,蔡亚玲.益母草总生物碱的药理实验研究[J].华中科技大学学报:医学版,2002,31(2)：168-170.
[11] 李素云,姜水印,卫洪昌,等.益母草生物碱和黄酮成分抗大鼠心肌缺血药效学研究[J].上海中医药大学学报,2006,20（1）：61-63.
[12] 金若敏,陈兆善,陈长勋,等.益母草治疗痛经机制探索[J].中国现代应用药学杂志,2004,21(2)：90-93.
[13] 高学敏.中药学[M].北京：中国中医药出版社,2002：381.
[14] 罗毅,冯晓东,刘红燕,等.益母草总生物碱对小鼠肝、肾的亚急性毒性作用[J].中国医院药学杂志,2010,30(1)：7-10.
[15] 陈红宾,周远鹏.五种益母草药理及毒性作用比较[J].北京针灸骨伤学院学报,1994,1(1)：38-40.
[16] 黄伟,孙蓉,张作平.益母草不同炮制品的小鼠急性毒性实验研究[J].中国药物警戒,2010,2(7)：65-69.
[17] 谢敏妍,杨柏雄.短期大剂量益母草对大鼠肾脏的影响[J].中国医药指南,2012,10(19)：8-9.