中国药物警戒 ›› 2023, Vol. 20 ›› Issue (8): 848-857.
DOI: 10.19803/j.1672-8629.20230004

• 药源性心脏毒性的警戒与机制研究专栏 • 上一篇    下一篇

西红花对阿霉素诱导的大鼠心律失常治疗作用研究

萨日娜1,2,3, 张冰1,2,*, 林志健1,2, 张晓朦1,2, 王雨1   

  1. 1北京中医药大学中药学院,北京 102488;
    2北京中医药大学中药药物警戒与合理用药研究中心,北京 102488;
    3甘肃省人民医院,甘肃 兰州 730000
  • 收稿日期:2023-01-02 出版日期:2023-08-15 发布日期:2023-08-07
  • 通讯作者: *张冰,女,教授·博导,主任医师,中药药物警戒与合理用药研究。E-mail：zhangbing6@263.net
  • 作者简介:萨日娜,女,博士,中药药物警戒与合理用药研究。
  • 基金资助:
    国家自然科学基金资助项目（82274117）; 国家中医药管理局中医药创新团队及人才支持计划子项目（ZYYCXTD-; C-202005-11）,甘肃省自然科学基金资助项目（23JRRA1297）

Therapeutic effect of saffron against arrhythmia induced by doxorubicin in rats

SA Rina1,2,3, ZHANG Bing1,2,*, LIN Zhijian1,2, ZHANG Xiaomeng1,2, WANG Yu1   

  1. 1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China;
    2Center for Pharmacovigilance and Rational Use of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China;
    3Gansu Provincial Hospital, Lanzhou Gansu 730000, China
  • Received:2023-01-02 Online:2023-08-15 Published:2023-08-07

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摘要： 目的 观察西红花对阿霉素诱导的心律失常治疗作用,为临床应用西红花抗阿霉素心脏毒性提供依据。方法 用阿霉素诱导心律失常模型,随机分为对照组（CONT）、模型组（DOX）、阳性对照药组（BFT）、西红花组（T-SE）。通过一般表现（状态、体重）、心脏损伤生物指标（CK-MB、BNP、NT-ProBNP、cTni）、心脏功能指标（超声心动图、心电图）、心脏病理指标等,综合考察西红花对DOX诱导的心律失常大鼠的治疗作用。结果 DOX诱导的心律失常模型大鼠经西红花治疗一周后,心电图显示：与DOX组相比,T-SE 组大鼠的QTC间期缩短,ST段时段减少,Q波幅度减少;超声心动图显示：与DOX组相比,T-SE 组的左心室射血分数（LVEF）、左心室短轴缩短率（LVFS）、左心室质量（LV Mass）等心功能指标显著增高（P < 0.05）,收缩末期左心室前壁厚度（LVAW;s）、舒张末期左心室后壁厚度（LVPW;d）、收缩末期左心室后壁厚度（LVPW;s）、舒张末期和收缩末期的室间隔厚度（IVS;d,IVS;s）均显著增高（P < 0.05）,收缩末期左心室内径（LVID;s）、收缩期容积（LV Vol;s）显著降低（P < 0.05）;心损生物标志物显示：与DOX组相比,T-SE组肌酸激酶MB同工酶（CK-MB）、大鼠心肌肌钙蛋白I（cTni）、脑钠素/脑钠尿肽（BNP）、N端前脑钠素（NT-proBNP）显著降低（P < 0.01）。结论 西红花能有效缓解DOX诱导的心律失常。

关键词: 西红花, 阿霉素, 大鼠, 心律失常, 心脏毒性

Abstract: Objective To observe the therapeutic effect of saffron against DOX-induced arrhythmias and provide data for clinical application of saffron against DOX cardiotoxicity. Methods An arrhythmia model was induced with adriamycin. The experimental rats were randomly divided into the control (CONT), model (DOX), positive drug (BFT), and saffron (T-SE) groups. The therapeutic effects of saffron against DOX-induced arrhythmia in rats were investigated in terms of general performance (status and body weight), biological indicators of cardiac injury (CK-MB, BNP, NT-ProBNP and cTni), cardiac functional indicators (cardiac ultrasound and ECG), and cardiac pathological indicators. Results One week after treatment with saffron in DOX arrhythmia model rats, ECG showed that the QTC interval was shortened, ST segment period was reduced, and Q wave amplitude was reduced in the T-SE group rats compared with the DOX group. Echocardiography suggested that left ventricular ejection fraction (LVEF), left ventricular fraction shortening (LVFS), and LV mass were significantly increased (P < 0.05), so were left ventricular anterior wall thickness at end-systole (LVAW;s), left ventricular posterior wall thickness at end-diastole (LVPW;d), left ventricular posterior wall thickness at end-systole (LVPW;s), interventricular septal thickness at end-diastole (IVS;d), and interventricular septal thickness end diastole (IVS;s) (P < 0.05), but left ventricular end-systolic dimension (LVEDD) and left ventricular end-systole volume (LVESV) were significantly decreased (P < 0.05) in the T-SE group compared with the DOX group. Cardiac damage biomarkers showed that creatine kinase MB(CK-MB), troponin I (cTnI), brain natriuretic peptide(BNP), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were significantly lower in the T-SE group than in the DOX group (P < 0.001). Conclusion Saffron is effective in alleviating DOX-induced arrhythmias.

Key words: saffron, doxorubicin, rat, arrhythmia, cardiotoxicity

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