1例甲氨蝶呤片严重中毒患者的药学监护

doi:10.19803/j.1672-8629.2022.08.23

中国药物警戒 ›› 2022, Vol. 19 ›› Issue (8): 924-928.
DOI: 10.19803/j.1672-8629.2022.08.23

• 安全与合理用药 • 上一篇

1例甲氨蝶呤片严重中毒患者的药学监护

原小陇¹, 万齐华^1*, 陶东红¹, 祁浩¹, 王爱霞²

¹西宁市第一人民医院药学部,青海西宁 810000;
²青海省人民医院药学部,青海西宁 810007

收稿日期:2020-10-21 出版日期:2022-08-15 发布日期:2022-08-15
通讯作者: ^*万齐华,男,本科,主管药师,临床药学。E-mail：15203286110@163.com
作者简介:原小陇,男,硕士,主管药师,静脉用药调配与医院药学。

Pharmaceutical care of a severely poisoned patient with methotrexate tablets

YUAN Xiaolong¹, WAN Qihua^1*, TAO Donghong¹, QI Hao¹, WANG Aixia²

¹Department of Pharmacy, the First People’s Hospital of Xining, Xining Qinghai 810000, China;
²Department of Pharmacy, People’s Hospital of Qinghai Province, Xining Qinghai 810007, China

Received:2020-10-21 Online:2022-08-15 Published:2022-08-15

摘要/Abstract

摘要： 目的探讨甲氨蝶呤片严重中毒患者的有效药物治疗方案。方法临床药师参与1例甲氨蝶呤片严重中毒患者的治疗过程,通过分析抗菌药物常见不良反应及药动学特点,结合细菌培养及相关检查指标,及时调整抗菌治疗方案;结合患者个体因素,尽早应用骨髓抑制解毒方案;结合患者凝血功能、生化指标及相关药物药理特性,针对性地选择合适的止血、抑酸、补液治疗方案。结果患者住院治疗后脱离生命危险,总体转归情况良好,顺利出院。结论临床药师在临床治疗中充分运用药学知识,协助医师调整用药方案,提高临床药物治疗水平。

关键词: 甲氨蝶呤中毒, 临床药师, 治疗方案, 药物治疗, 药品不良反应

Abstract: Objective To explore the effective medication plan for a patient with severe methotrexate poisoning. Methods Clinical pharmacists participated in the treatment of a patient with severe methotrexate poisoning. By analyzing the common adverse reactions and pharmacokinetic characteristics of antibiotics and based on bacterial culture and related examination indexes, clinical pharmacists recommended quickly adjusting the antibacterial treatment plan. Given the individual factors of the patient, clinical pharmacists advised the clinicians to adopt the bone marrow suppression detoxification scheme as soon as possible. According to the coagulation function, biochemical indexes and pharmacological characteristics of related drugs, the clinical pharmacists gave tips on ways of appropriate hemostasis, acid suppression, and fluid replacement. Results After hospitalization, the patient was out of danger, the overall outcome was good, and she was discharged. Conclusion Clinical pharmacists can assist clinicians in adjusting the drug regimen and improve the level of clinical medication by making full use of their knowledge of pharmaceuticals.

Key words: methotrexate poisoning, clinical pharmacist, treatment programs, drug therapy, adverse drug reaction

中图分类号:

R915
994.11

原小陇, 万齐华, 陶东红, 祁浩, 王爱霞. 1例甲氨蝶呤片严重中毒患者的药学监护[J]. 中国药物警戒, 2022, 19(8): 924-928.

YUAN Xiaolong, WAN Qihua, TAO Donghong, QI Hao, WANG Aixia. Pharmaceutical care of a severely poisoned patient with methotrexate tablets[J]. Chinese Journal of Pharmacovigilance, 2022, 19(8): 924-928.

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1例甲氨蝶呤片严重中毒患者的药学监护

Pharmaceutical care of a severely poisoned patient with methotrexate tablets

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