中国药物警戒 ›› 2022, Vol. 19 ›› Issue (8): 919-920.
DOI: 10.19803/j.1672-8629.2022.08.21

• 安全与合理用药 • 上一篇    下一篇

注射用盐酸丙帕他莫致严重双上肢静脉血栓2例分析

张涛1, 赵静1, 李静1, 李茂星1, 冯霞2, 林通3*   

  1. 1中国人民解放军联勤保障部队第九四○医院临床药学科,甘肃 兰州730050;
    2中国人民解放军联勤保障部队第九四○医院护理部,甘肃 兰州 730050;
    3中国人民解放军联勤保障部队第九四○医院卫勤部,甘肃 兰州 730050
  • 收稿日期:2020-12-01 出版日期:2022-08-15 发布日期:2022-08-15
  • 通讯作者: *林通,男,主治医师,医院管理。E-mail：1245713477@qq.com
  • 作者简介:张涛,女,硕士,主管中药师,临床药学。
  • 基金资助:
    甘肃省卫生行业科研护理计划项目(GSWSKY- 2019-57)

Pharmacovigilance of propacetamol hydrochloride for injection

ZHANG Tao1, ZHAO Jing1, LI Jing1, LI Maoxing1, FENG Xia2, LIN Tong3*   

  1. 1Department of Clinical Pharmacy, 940th Hospital of Joint Logistics Support Force of PLA, Lanzhou Gansu 730050, China;
    2Department of Nurse, 940th Hospital of Joint Logistics Support Force of PLA, Lanzhou Gansu 730050, China;
    3Department of Medicine, 940th Hospital of Joint Logistics Support Force of PLA, Lanzhou Gansu 730050, China
  • Received:2020-12-01 Online:2022-08-15 Published:2022-08-15

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摘要： 目的 通过2例使用盐酸丙帕他莫致严重药品不良反应分析,提出该药的用药警戒。方法 对2例使用注射用盐酸丙帕他莫致严重双上肢静脉血栓的病例进行回顾性分析。结果 注射用盐酸丙帕他莫配置浓度过低、滴注速度过慢以及疗程过长导致患者发生严重双上肢静脉血栓。结论 医师用药前要仔细询问患者过敏史,给予合理的剂量,合理的给药途径,严格按照注射用盐酸丙帕他莫说明书要求配置和输注,所用溶媒为氯化钠注射液100 mL,输注时间为15 min,不得长期使用。

关键词: 药物警戒, 盐酸丙帕他莫, 药品不良反应, 静脉血栓

Abstract: Objective To provide pharmacovigilance of propacetamol hydrochloride for injection by 2 cases of severe adverse drug reactions. Methods A retrospective analysis was performed on 2 cases of severe bilateral upper limb venous thrombosis caused by propacetamol hydrochloride for injection. Results The heavy concentrations, fast intravenous infusion and long course of treatment of propacetamol hydrochloride for injection lead to patient severe bilateral upper limb venous thrombosis. Conclusion Patients' allergy history should be carefully asked before any treatment of drugs with a reasonable dose and a reasonable route. Clinical using of propacetamol hydrochloride for injection should be strictly followed its instructions. The solvent should be NS 100ml and the infusion time is 15 minutes. Long-term and off-label indications should be forbidden.

Key words: pharmacovigilance, propacetamol hydrochloride, adverse drug reactions, vein thrombosis

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