456例新型冠状病毒肺炎患者抗病毒药物应用分析

doi:10.19803/j.1672-8629.2022.04.15

摘要/Abstract

摘要： 目的对新型冠状病毒肺炎（COVID-19）患者的临床特点及抗病毒药物应用现状进行分析,为临床合理用药提供参考。方法收集2020年2月1日至29日仙桃市第一人民医院456例COVID-19患者的病例资料,对患者特征、抗病毒药物用法用量、联合使用情况及药品不良反应（ADR）进行回顾性分析。结果 456例COVID-19患者中,30~65岁患者占71.71%,抗病毒药物用法用量基本符合国家诊疗方案,单药治疗为主,联用用药比例为8.78%,阿比多尔使用频率最高,29例患者发生了ADR,主要表现为恶心、呕吐、纳差。结论我院COVID-19患者抗病毒药物使用基本合理,少数患者抗病毒药物品种达3种以上,应重视其合理性和安全性。

关键词: 新型冠状病毒肺炎, 抗病毒药物, 回顾性研究, 药品不良反应

Abstract: Objective To evaluate the clinical characteristics of COVID-19 patients and current usage of antiviral drugs in our hospital to provide data for rational use drugs in cliuic. Methods The clinical data on COVID-19 patients diagnosed in Xiantao First People's Hospital from February 1 to February 29, 2020, their characteristics, as well as the usage, dosage and combined use of antiviral drugs and adverse drug reactions (ADR) were analyzed retrospectively. Results A total of 456 patients were collected. Patients aged 30 to 65 accounted for 71.71%. The usage and dosage of antiviral drugs basically conformed to the national diagnosis and treatment plans. Monotherapy was the main treatment, combined use of antiviral drugs accounted for 8.78%, and arbidol was the most frequently used. ADR occurred in 29 patients, and the main symptoms were nausea, vomiting and poor appetite. Conclusion The use of antiviral drugs in patients with COVID-19 was generally appropriate, but a few patients were treated with three or more types of antiviral drugs.

Key words: coronavirus disease 2019 (COVID-19), antiviral drug, retrospective study, adverse drug reaction

中图分类号:

R978.7

杨帆, 马海平, 尤萌茹, 廖沙, 刘兰, 朱军. 456例新型冠状病毒肺炎患者抗病毒药物应用分析[J]. 中国药物警戒, 2022, 19(4): 413-416.

YANG Fan, MA Haiping, YOU Mengru, LIAO Sha, LIU Lan, ZHU Jun. Applications of antiviral drugs in 456 patients with COVID-19[J]. Chinese Journal of Pharmacovigilance, 2022, 19(4): 413-416.

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