中国药物警戒 ›› 2022, Vol. 19 ›› Issue (4): 408-412.
DOI: 10.19803/j.1672-8629.2022.04.14

• 安全与合理用药 • 上一篇    下一篇

利巴韦林在我国7个城市儿科应用现状与合理应用评价

杨淼1,2,3, 杨莉1, 赵志刚1,2,*   

  1. 1首都医科大学附属北京天坛医院药学部,北京 100070;
    2首都儿科研究所附属儿童医院药学部,北京 100020;
    3首都医科大学药学院,北京 100069
  • 收稿日期:2020-05-22 出版日期:2022-04-15 发布日期:2022-04-15
  • 通讯作者: *赵志刚,男,教授,主任药师,药事管理与临床药学。E-mail：1022zzg@sina.com
  • 作者简介:杨淼,女,本科,药师,临床药物治疗与合理用药。
  • 基金资助:
    北京市医院管理局临床医学发展专项（ZYLX-201827）

Current applications and rationality of ribavirin in pediatrics in seven cities in China

YANG Miao1,2,3, YANG Li1, ZHAO Zhigang1,2,*   

  1. 1Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China;
    2Department of Pharmacy, Children's Hospital, Capital Institute of Pediatrics, Beijing 100020, China;
    3School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China
  • Received:2020-05-22 Online:2022-04-15 Published:2022-04-15

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摘要： 目的 调查利巴韦林在我国7个城市儿科应用现状,初步评价其在儿科应用的合理性,为促进利巴韦林的合理使用提供参考。方法 分析数据来源于中国药学会医院药学专业委员会“医院处方分析合作项目”,2013 年 1 月1日至 2017 年 12 月31日抽取7个城市107家医疗机构的样本处方,统计相关信息,以国内外利巴韦林说明书、相关指南为依据,评价处方合理性。结果 利巴韦林在抗病毒药物的应用中占很大比例（49.4%）。儿科主要用于呼吸道感染、手足口病、支气管炎、肺炎以及疱疹性咽峡炎等。应用利巴韦林的儿童患者主要集中在1~2岁和3~5岁。儿科应用最多的剂型为注射剂（40.43%）。结论 利巴韦林的应用存在超适应证和超年龄使用的不合理性,应建立针对利巴韦林的处方点评制度,规范其在儿科的应用。

关键词: 利巴韦林, 儿科, 用药现状, 适应证, 剂型

Abstract: Objective To evaluate the rationality of ribavirin in pediatric use and to provide the basic data for rational use of ribavirin. Methods Sample prescriptions from 107 health institutions in 7 cities in China were included after searching "The Hospital Prescriptions Cooperation Project" by Hospital Pharmacy Professional Committee of Chinese Pharmaceutical Association from January 1, 2013 to December 31, 2017 to assess the rationality of related prescriptions based on domestic and foreign prescriptions of ribavirin and related guidelines. Results Ribavirin accounted for a large proportion of antiviral drugs(49.4%). Ribavirin was mainly used in pediatrics in China for respiratory tract infections, hand-foot-and-mouth disease, bronchitis, pneumonia and herpangina. The children who used ribavirin were mostly aged 1 to 2 and 3 to 5. The most commonly used dosage form of ribavirin was injection(40.43%). Conclusion There is some off-label or beyond-the-age-limit use of ribavirin in China, so a prescription rating system for ribavirin should be established to regulate the applications in pediatrics in China.

Key words: ribavirin, pediatrics, medication status, indications, dosage form

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