930例儿童抗菌药物不良反应分析

doi:10.19803/j.1672-8629.2022.03.19

中国药物警戒 ›› 2022, Vol. 19 ›› Issue (3): 317-321.
DOI: 10.19803/j.1672-8629.2022.03.19

930例儿童抗菌药物不良反应分析

徐喆, 鞠萍, 罗琪, 杨欢, 汪洋^*

马鞍山市妇幼保健院药剂科,安徽马鞍山 243000

收稿日期:2020-05-17 出版日期:2022-03-15 发布日期:2022-03-16
通讯作者: ^*汪洋,男,硕士,副主任药师,临床药学与医院药学。E-mail：wy_mas@163.com
作者简介:徐喆,女,硕士,主管药师,临床药学与医院药学。

930 cases of adverse drug reactions induced by antibacterial drugs in children

XU Zhe, JU Ping, LUO Qi, YANG Huan, WANG Yang^*

Department of Pharmacy, Ma'anshan Municipal Health Hospital for Women and Children, Ma'anshan Anhui 243000, China

Received:2020-05-17 Online:2022-03-15 Published:2022-03-16

摘要/Abstract

摘要： 目的分析儿童抗菌药物所致不良反应发生的特点及规律,为临床安全用药提供参考。方法采用回顾性调查方法,对2017年1月1日至2019年12月31日马鞍山市妇幼保健院上报至国家药品不良反应监测系统930例儿童抗菌药物的药品不良反应（adverse drug reaction,ADR）报告进行统计分析。结果 930例儿童ADR报告中,男性565例,占60.75%;女性365例,占39.25%。6岁以下患儿ADR发生率高,占88.07%。静脉滴注是引发ADR最主要给药途径,共921例,占99.03%。引发ADR最多的抗菌药物品种是大环内酯类,共637例,占68.49%。胃肠系统损害是最主要的临床表现,共949例,占77.09%。报告者以药师为主,上报868份报告,占93.33%。绝大多数ADR经相应处理后痊愈或好转。结论抗菌药物引发ADR影响因素多且复杂,应加强儿童患者抗菌药物致ADR的监测,更好地保障临床用药安全。

关键词: 抗菌药物, 儿童, 药品不良反应, 合理用药

Abstract: Objective To analyze the characteristics of adverse drug reactions induced by antibacterial drugs in children so as to provide reference for safe clinical drug use. Methods A total of 930 reports of ADR induced by antibacterial drugs in children submitted by our hospital to the National ADR Monitoring Center between 2017 to 2019 were analyzed retrospectively. Results Among the 930 cases of ADR reported, 565 (60.75%) were males and 365 (39.25%) were females. The incidence of ADR in patients aged 0 to 6 was the highest (88.07%). Most of the cases of ADR were induced by intravenous injection, accounting for 99.03%. 637 of these cases (68.49%) were induced by macrolides. The injury to the gastrointestinal system was the most common ADR, which accounted for 93.33% of the total. Most of these ADR were cured or improved after corresponding treatment. Conclusion The influencing factors of ADR induced by antibacterial drugs are complicated. The monitoring of ADR in children should be upgraded so as to promote rational use of drugs and ensure safe and effective drug use in clinic.

Key words: antibacterial drugs, children, adverse drug reaction, rational use of drugs

中图分类号:

R994.11

徐喆, 鞠萍, 罗琪, 杨欢, 汪洋. 930例儿童抗菌药物不良反应分析[J]. 中国药物警戒, 2022, 19(3): 317-321.

XU Zhe, JU Ping, LUO Qi, YANG Huan, WANG Yang. 930 cases of adverse drug reactions induced by antibacterial drugs in children[J]. Chinese Journal of Pharmacovigilance, 2022, 19(3): 317-321.

参考文献

[1] National Medical Products Administration. Administrative Measures on Reporting and Monitoring of ADR (Order No. 81 of the Ministry of Health)[EB/OL]. (2011-05-04) [2020-05-17]. http://www.nmpa.gov.cn/WS04/CL2174/300642.html.
[2] WANG RQ,HUO YF,XIE YJ,et al.Retrospective analysis of 530 cases of new/severe pediatric ADR in Shandong Province during 2016-2017[J]. China Pharmacy(中国药房),2019,30(1):115-119.
[3] National Medical Products Administration. Notice on Issuing the Annual Report of National Adverse Drug Reaction Monitoring (2019)[EB/OL]. (2020-04-10) [2020-05-17]. http://www.cdr-adr.org.cn/tzgg_home/202004/t20200410_47300.html.
[4] China Food and Drug Administration. Technical Guidelines for Pharmacokinetic Studies in Pediatric Population[EB/OL]. (2014-07-11) [2020-05-17]. http://www.sda.gov.cn/WS01/CL0844/103095.html.
[5] ZHONG NS.Guiding Principles of Clinical Use of Antibiotics(2015)(抗菌药物临床应用指导原则(2015年版))[M]. Beijing:People's Medical Publishing House, 2015.
[6] Uppsala Monitoring Centre. What is WHO-ART[EB/OL]. (2019-04-25)[2019-04-25]. https://www.who-umc.org/vigibase/services/learn-more-about-who-art/.
[7] LIANG H, WEI FH, ZHONG LQ.Analysis of 233 cases of adr induced by antibacterials in our hospital[J].China Pharmacy(中国药房), 2016, 27(5):632-634.
[8] WANG YP, ZHONG W.Analysis on 687 reports of adverse drug reaction of children caused by antibacterial agents[J]. Anti Infect Pharm(抗感染药学), 2018, 15(10):1755-1757.
[9] ZHENG C.Analysis of Influencing factors of adverse reaction induced by antibacterial drugs in 222 children in a hospital[J]. China Licensed Pharmacist(中国执业药师), 2016, 13(11): 44-47.
[10] ZHOU LF, JIANG Y, ZHONG W, et al.Analysis of 332 cases of adverse drug reactions of children in our hospital[J]. Northwest Pharmaceutical Journal(西北药学杂志), 2019, 34(2): 272-275.
[11] Editorial board of Chinese National Formulary. Chinese National Formulary(Chemicals and Biological Products for Children)(中国国家处方集(化学药品与生物制品卷•儿童版))[M]. Beijing:People's Military Medical Press, 2013.
[12] ZHONG W, MAO CM, WANG M.Retrospective analysis of 562 cases of pediatric adverse drug reactions[J]. Journal of Pediatric Pharmacy(儿科药学杂志), 2018, 24(10): 39-42.
[13] MA J, MAO CM.Analysis of 408 pediatric cases with adverse drug Reaction[J]. Anhui Medical and Pharmaceutical Journal(安徽医药),2017, 21(6): 1150-1153.
[14] ZHOU L, SHI YP, HOU HL, et al.Adverse drug reactions in 108 children[J]. Journal of Pediatric Pharmacy(儿科药学杂志),2019, 25(4): 51-53.
[15] HIAMG CL, GUO DH, ZHU M, et al.Analysis on 9819 cases of ADR/ADE associated with quinolones in military hospitals[J]. Chinese Journal of Drug Application and Monitoring(中国药物应用与监测), 2017, 14(5): 293-296.
[16] ZHOU P, ZHU HY, CUI L.Investigation and analysis of adr reported and causes of missing reports by medical staff in a third grade class a hospital[J]. China Pharmacy(中国药房),2017, 28(36): 5056-5059.
[17] ZHANG Q.Retrospective analysis of 147 cases of adverse drug reactions[J]. Anhui Medical and Pharmaceutical Journal(安徽医药), 2019, 23(4): 846-848.
[18] WANG Y, XU Z.Analysis of 176 Pediatric ADR reports in our hospital[J]. China Pharmacy(中国药房), 2016, 27(26): 3649-3651.
[19] MENG XQ, ZHAO N, ZUO J, et al.Analysis of adverse drug reactions in reports of children and maternal in a hospital[J]. Anhui Medical and Pharmaceutical Journal(安徽医药),2017,21(10): 1938-1942.

930例儿童抗菌药物不良反应分析

930 cases of adverse drug reactions induced by antibacterial drugs in children

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	孙绮悦, 赵荣华, 包蕾, 郭姗姗, 耿子涵, 李舒冉, 徐英莉, 张敬升, 崔晓兰, 孙静. 基于多动物模型药效评价体系研究羚羊感冒口服液儿童用药剂量[J]. 中国药物警戒, 2024, 21(2): 121-126.
[2]	贾晋生, 刘红亮, 王青, 侯永芳, 李馨龄. 基于知识图谱联合ERNIE-DPCNN模型的药品不良反应自动关联性评价方法研究[J]. 中国药物警戒, 2024, 21(2): 163-166.
[3]	范凯凯, 王聪, 刘洪峰, 王西勇. 临床药师对某院丙氨酰谷氨酰胺注射液应用干预分析[J]. 中国药物警戒, 2024, 21(2): 181-184.
[4]	李应芬, 韩雷. 319例注射用脑蛋白水解物药品不良反应报告分析[J]. 中国药物警戒, 2024, 21(2): 195-198.
[5]	徐伟佳, 彭崎, 黄海渝, 张磊姣, 肖华, 吴雪. 285例新型抗肿瘤药物不良反应分析[J]. 中国药物警戒, 2024, 21(2): 199-203.
[6]	郭清华, 彭笑笑, 朱萍, 刘西霖, 杨颖华, 陈志海. 氨氯地平过量致多器官功能障碍综合征1例分析[J]. 中国药物警戒, 2024, 21(2): 204-207.
[7]	方美琳, 郑慧敏, 王存泽, 王凌, 阮君山. 注射用奥沙利铂致全身肌肉疼痛1例分析[J]. 中国药物警戒, 2024, 21(2): 208-210.
[8]	陈玉艳, 张明霞, 张涛, 张晋. 斯鲁利单抗注射液致间质性肺炎不良反应1例分析[J]. 中国药物警戒, 2024, 21(2): 213-215.
[9]	曹桂萍, 邓琳琳, 朱干红, 陆颖, 马爽, 陈玲玲, 刘丽丽. 天麻首乌片致严重肝损伤1例分析[J]. 中国药物警戒, 2024, 21(2): 216-218.
[10]	高云娟, 赵旭, 白天凯, 柏兆方, 王伽伯, 宋海波, 肖小河. 基于不良反应监测大数据的药品安全风险发现与识别策略[J]. 中国药物警戒, 2024, 21(1): 1-5.
[11]	郭龙鑫, 高云娟, 吴承钊, 龙敏娟, 祝胜凯, 宋海波, 赵旭, 肖小河. 基于不良反应监测大数据的中药药源性肝损伤风险信号新发现及易感因素初探[J]. 中国药物警戒, 2024, 21(1): 15-19.
[12]	蒋文硕, 杨莉. 694例癫痫医师药师联合门诊患者药品不良反应分析[J]. 中国药物警戒, 2024, 21(1): 102-106.
[13]	陈华炎, 江东波, 郭春连, 杨家琪, 黎雨欣, 蔡伟明. 326例奈玛特韦片/利托那韦片治疗新型冠状病毒感染安全性分析[J]. 中国药物警戒, 2024, 21(1): 107-110.
[14]	刘赛月, 吕小琴, 周耘. 疑似药品不良反应死亡病例调查及报告实施要点[J]. 中国药物警戒, 2023, 20(9): 971-974.
[15]	里筱竹, 王蔷, 逄瑜, 张轶菁. 个例药品不良反应报告管理浅析与思考[J]. 中国药物警戒, 2023, 20(9): 975-977.