住院患者皮肤药品不良反应及伴随的肝肾功能异常分析

doi:10.19803/j.1672-8629.2022.03.17

中国药物警戒 ›› 2022, Vol. 19 ›› Issue (3): 310-312.
DOI: 10.19803/j.1672-8629.2022.03.17

住院患者皮肤药品不良反应及伴随的肝肾功能异常分析

靳浩槟, 郑磊, 杨静, 管玉瑶, 张晓丽^*

山东省立第三医院,山东济南 250031

收稿日期:2020-05-06 出版日期:2022-03-15 发布日期:2022-03-16
通讯作者: ^*张晓丽,女,副主任药师,医院药学。E-mail：sdsjtyyyjk@163.com。
作者简介:靳浩槟,男,硕士,药师,临床药学。
基金资助:
中国药学会科技开发中心精准用药科技传播促进行动2019年重点项目[CMEI2019KPYJ(JZYY)00204]; 山东省医学会治疗药物监测临床科研专项资金项目（YXH2020ZX047）; 山东省医学会临床药学科研专项资金项目（YXH2019ZX016）; 山东省医药卫生科技发展计划项目(2017WS473)

Adverse reactions of skin drugs and concomitant liver and kidney dysfunction in inpatients

JIN Haobin, ZHENG Lei, YANG Jing, GUAN Yuyao, ZHANG Xiaoli^*

Shandong Provincial Third Hospital, Jinan Shandong 250031, China

Received:2020-05-06 Online:2022-03-15 Published:2022-03-16

摘要/Abstract

摘要： 目的研究分析临床药物应用与皮肤药品不良反应（adverse drug reaction, ADR）发生的相关性及防治策略,促进临床合理用药。方法统计和分析我院2007年7月1日至2018年12月31日收集的858例药物引起的皮肤ADR病例。结果 858例皮肤ADR病例涉及的药物共有266种,以抗生素注射剂、理血药、营养支持药为主,给药途径以静脉给药为主（63.16%）,口服给药占25.19%。一般ADR 747例,严重ADR 71例,新的ADR 38例。100例皮肤ADR同时伴随谷丙转氨酶、谷草转氨酶、血肌酐值异常。结论药物引起的皮肤ADR以皮疹、瘙痒为主且常伴随肝肾功能损害,临床医生应当根据患者的原发疾病、过敏史和各类药物不同的特性,评估ADR风险,制定个体化给药方案,减少ADR的发生。

关键词: 皮肤, 药品不良反应, 合理用药

Abstract: Objective To study and analyze the correlations between clinical drug use and adverse drug reactions (ADR) related to skin drugs in order to promote rational drug use in clinic. Methods Eight hundred and fifty-eight cases of drug-induced skin ADR treated in our hospital between July 1, 2007 and December 31, 2018 were collected and statistically analyzed. Results There were 266 types of drugs involved in 858 cases of skin ADR, including antibiotic injection, blood-regulating formula and nutritional support drugs. The main routes of administration were intravenous administration (63.16%) and oral administration (25.19%). There were 747 cases of mild ADR, 71 serious ADR and 38 new ADR. 100 of these cases of skin ADR were accompanied by abnormal levels of glutamic pyruvic transaminase, glutamic oxaloacetic transaminase and serum creatinine. Conclusions kin ADR induced by drugs are mainly skin rash and pruritus, which are often accompanied by liver and kidney injury. Clinicians should assess the risk of ADR according to the patients' preexisting diseases, history of allergy and properties of various drugs, develop individualized drug delivery plans, and reduce the occurrence of ADR.

Key words: skin, adverse drug reaction, rational drug use

中图分类号:

R994.11

靳浩槟, 郑磊, 杨静, 管玉瑶, 张晓丽. 住院患者皮肤药品不良反应及伴随的肝肾功能异常分析[J]. 中国药物警戒, 2022, 19(3): 310-312.

JIN Haobin, ZHENG Lei, YANG Jing, GUAN Yuyao, ZHANG Xiaoli. Adverse reactions of skin drugs and concomitant liver and kidney dysfunction in inpatients[J]. Chinese Journal of Pharmacovigilance, 2022, 19(3): 310-312.

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住院患者皮肤药品不良反应及伴随的肝肾功能异常分析

Adverse reactions of skin drugs and concomitant liver and kidney dysfunction in inpatients

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