中国药物警戒 ›› 2022, Vol. 19 ›› Issue (1): 95-99.
DOI: 10.19803/j.1672-8629.2022.01.21

• 安全与合理用药 • 上一篇    下一篇

垂体后叶注射液致药品不良反应文献分析

谢晓燕1, 夏旭东2, 杨雪2, 李清芳1, 刘翠丽3, 陈世伟2,*   

  1. 1开封市药品不良反应监测中心,河南 开封 475000;
    2河南省食品药品评价中心,河南 郑州 450004;
    3国家药品监督管理局药品评价中心,国家药品监督管理局药物警戒研究与评价重点实验室,北京 100045
  • 收稿日期:2020-02-25 出版日期:2022-01-15 发布日期:2022-01-20
  • 通讯作者: *陈世伟,男,博士,副主任医师,药械安全性监测。E-mail：henanadr@126.com
  • 作者简介:谢晓燕,女,硕士,副主任药师,药械安全性监测。

Literature analysis of adverse drug reactions induced by posterior pituitary injection

XIE Xiaoyan1, XIA Xudong2, YANG Xue2, LI Qingfang1, LIU Cuili3, CHEN Shiwei2,*   

  1. 1Kaifeng Center for ADR Monitoring, Kaifeng Henan 475000, China;
    2Food and Drug Reevaluation Center of Henan Province, Zhengzhou Henan 450004, China;
    3Center for Drug Reevaluation, NMPA/NMPA, Key Laboratory for Research and Evaluation of Pharmacovigilance, Beijing 100045, China
  • Received:2020-02-25 Online:2022-01-15 Published:2022-01-20

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摘要： 目的 探讨垂体后叶注射液致不良反应的一般规律、特点及相关风险因素,为临床安全用药提供参考。方法 以“垂体后叶注射液”“不良反应”等为检索词,检索中国知网（CNKI）、维普网（VIP）及万方数据中建库以来至2019年4月30日报道的涉及垂体后叶注射液所致不良反应的文献资料,按纳入与排除标准共纳入159篇文献,进行资料提取和统计分析。结果 垂体后叶注射液不良反应可累及多个系统-器官,以低钠血症、胃肠道损害最为常见,严重者可致低钠性脑病、心跳骤停等。结论 重视垂体后叶注射液引发的不良反应,密切防范不良反应的发生,确保临床用药安全。

关键词: 垂体后叶注射液, 药品不良反应, 低血钠血症, 胃肠道损害

Abstract: Objective To study the pattern, characteristics and influencing factors of adverse reactions induced by posterior pituitary injection so as to provide reference for clinical safe medication. Methods Based on such key words as“pituitrin injection”and“adverse reactions”, literature was searched for that was related to the adverse reactions caused by pituitrin injection reported in CNKI, VIP and Wanfang databases between inception and April 30, 2019. According to the inclusion and exclusion criteria, 159 articles were included for data retrieval and statistical analysis. Results The adverse reactions involved multiple organs and systems. The most common reactions were hyponatremia and gastrointestinal tract damage. In severe cases, hyponatremia encephalopathy and cardiac arrest were likely. Conclusion The adverse reactions caused by posterior pituitary injection deserve attention, and efforts have to be made to guard against the occurrence of adverse reactions to ensure the safety of clinical medication.

Key words: posterior pituitary injection, adverse drug reactions, hyponatremia, gastrointestinal tract damage

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