生物信息技术预警乌头类中药抗乳腺癌用药风险

doi:10.19803/j.1672-8629.2021.07.13

中国药物警戒 ›› 2021, Vol. 18 ›› Issue (7): 655-662.
DOI: 10.19803/j.1672-8629.2021.07.13

生物信息技术预警乌头类中药抗乳腺癌用药风险

王雨¹, 林志健^1,2, 姜卓希¹, 杨婷¹, 王笑¹, 张冰^1,2,*

¹北京中医药大学中药学院,北京 100029;
²北京中医药大学中药药物警戒与合理用药研究中心,北京 100029

收稿日期:2019-12-16 出版日期:2021-07-15 发布日期:2021-07-23
通讯作者: ^*张冰,女,博士,教授·博导,中药防治代谢性疾病研究、中药药物警戒与合理用药。E-mail：zhangbing6@263.net
作者简介:王雨,女,博士,中药防治代谢性疾病研究,中药药物警戒与合理用药。
基金资助:
国家自然科学基金资助项目（81673618）

Early Warning of Aconitum Herbs in Breast Cancer Therapy by Bibliometric and Bioinformatics

WANG Yu¹, LIN Zhijian^1,2, JIANG Zhuoxi¹, YANG Ting¹, WANG Xiao¹, ZHANG Bing^1,2,*

¹School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100029, China;
²Center for Pharmacovigilance and Rational Use of Chinese Medicine, Beijing 100029, China

Received:2019-12-16 Online:2021-07-15 Published:2021-07-23

摘要/Abstract

摘要： 目的以乌头类中药抗乳腺癌研究为例,探讨毒性中药治疗恶性肿瘤的用药风险预警。方法采用文献计量学手段分析乌头类中药的不良反应/事件（ADR/AE）。采用生物信息学技术,提取基因表达数据库（gene expression omnibus, GEO）中芯片数据集GSE85871,对乌头类中药中主要生物碱成分对乳腺癌细胞MCF7差异表达基因进行基因本体论（gene oncology, GO）注释、京都基因组与基因百科全书（Kyoto encyclopedia of genes and genomes, KEGG）通路富集及蛋白质互作网络分析。结果乌头类中药治疗乳腺癌的过程中,可能会伴随醛固酮合成分泌途径、内分泌代谢途径、神经化学转导途径及骨代谢途径异常。结论在应用乌头类中药治疗乳腺癌时,须对患者循环系统、神经系统、内分泌系统、骨骼系统相关机体状态进行整体评价及密切关注,综合评估用药风险。

关键词: 乌头类中药, 乳腺癌, 用药风险预警, 文献计量学, 生物信息技术

Abstract: Objective To explore the rational application of traditional Chinese medicine in cancer therapies via the treatment of breast cancer with aconitum herbs. Methods Methods of bibliometric and bioinformatics were employed. The microarray data of GSE85871 was downloaded from GEO database and analyzed by means of Gene Ontology (GO) annotation, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis and protein-protein interaction networks. Results The treatment of breast cancer with aconitum herbs might be accompanied by abnormalities of pathways of aldosterone synthesis and secretion, endocrine metabolism, neurochemical transduction and bone metabolism. Conclusion The circulatory system, nervous system, endocrine system and skeletal system deserve attention before and during medication with aconitum herbs.

Key words: aconitum herbs, breast cancer, early warning of medication risk, bibliometrics, bioinformatics

中图分类号:

王雨, 林志健, 姜卓希, 杨婷, 王笑, 张冰. 生物信息技术预警乌头类中药抗乳腺癌用药风险[J]. 中国药物警戒, 2021, 18(7): 655-662.

WANG Yu, LIN Zhijian, JIANG Zhuoxi, YANG Ting, WANG Xiao, ZHANG Bing. Early Warning of Aconitum Herbs in Breast Cancer Therapy by Bibliometric and Bioinformatics[J]. Chinese Journal of Pharmacovigilance, 2021, 18(7): 655-662.

参考文献

[1] Cao MM, Chen WQ.Epidemiology of cancer in China and the current status of prevention and control[J]. Chinese Journal of Clinical Oncology(中国肿瘤临床), 2019, 46(3): 145-149.
[2] Xu JY, Huang YY.Research progress of toxic traditional Chinese medicine in treating malignant tumor[J]. Chinese Journal of Ethnomedicine and Ethnopharmacy(中国民族民间医药), 2017, 26(21): 53-58.
[3] Gu XD, Xu LL, Zhao H, et al.Cantharidin suppressed breast cancer MDA-MB-231 cell growth and migration by inhibiting MAPK signaling pathway[J]. Brazilian Journal of Medical Biological Research, 2017, 50(7): e5920.
[4] Huang G, Yang L, Zhou W, et al.Study on cardiotoxicity and mechanism of "fuzi" extracts based on metabonomics[J]. Interna-tional Journal of Molecular Sciences, 2018, 19(11): 3506.
[5] Xu XL, Yang LJ, Jiang JG.Renal toxic ingredients and their toxicology from traditional Chinese medicine[J]. Expert Opinion on Drug Metabolism & Toxicology, 2016, 12(2): 149-59.
[6] Zhang XM, Lin ZJ, Zhang B, et al.Comparison of aconitum with tripterygium in treatment of axial spondyloarthritis: a benefit-risk assessment[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2018, 15(2): 103-109.
[7] Zhang XM, Jin YN, Zhang B, et al.Aconitum in treatment of rheumatoid arthritis: benefit-risk assessment[J]. China Journal of Chinese Materia Medica(中国中药杂志), 2018, 43(2): 234-241.
[8] Wang D, Jia DX, Li ZZ, et al.Safety evaluation and risk control measures for Aconiti Kusnezoffii Radix[J]. China Journal of Chinese Materia Medica(中国中药杂志), 2018, 43(15): 3093-3100.
[9] Zhang XM, Lin ZJ, Zhang B, et al.Risk-benefit assessment of aconitum napellus[J]. China Journal of Chinese Materia Medica(中国中药杂志), 2018, 33(6): 2221-2224.
[10] Zhang XM, Li F, Zhang B, et al.Data-mining characteristics of adverse drug reactions and pharmacovigilance of Chinese patent drugs including aconitum herbs[J]. China Journal of Chinese Materia Medica(中国中药杂志), 2018, 43(2): 234-241.
[11] Song LJ, Ji XM, Wang HR, et al.Review on treating tumor by wen yang method[J]. Information on Traditional Chinese Medicine(中医药信息), 2015, 32(1): 118-121.
[12] Ng AWT, Poon SL, Huang MN, et al. Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throug-hout Asia[J]. Science Translational Medicine, 2017, 9(412): eaan 6446.
[13] Zhang JL, Mao R, Du G.Research advance on alkaloids and their pharmacological effects of Radix Aconite[J]. Herald of Medicine(医药导报), 2019, 38(8): 1048-1051.
[14] Sanguinetti A, Santini D, Bonafè M, et al.Interleukin-6 and pro inflammatory status in the breast tumor microenvironment[J]. World Journal of Surgical Oncology, 2015, 13(1): 129.
[15] Zhang W, Sun HC, Wang WQ, et al.Sorafenib down-regulates expression of HTATIP2 to promote invasiveness and metastasis of orthotropic hepatocellular carcinoma tumors in mice[J].Gastroenterology, 2012, 143(6): 1641-1649.
[16] Jing CP, He JZ, Wei XL.Inflammatory cytokines IL-1beta, IL-8, the relationship between the TNF-alpha and breast cancer[J]. Journal of Yanan University(Medical Science Edition)(延安大学学报(医学科学版)), 2014, 12(3): 61-63.
[17] Wang M.Research progress of aldosterone and its receptor antagonists in cardiovascular disease[J]. Journal of Mathematical Medicine(数理医药学杂志), 2017, 30(4): 592-594.
[18] Peng HW, Shi RZ, Yuan XF, et al.The anti-apoptotic effect of c-fos in drug-resistant breast cancer cells[J]. China Oncology(中国癌症杂志), 2014, 24(8): 581-588.
[19] Zhang YD, Zhu PF, Wang ZG, et al.Effect of severe traumatic injury on expression of c-fos and corticotropin-releasing hormone in the hypothalamus of rats[J]. Journal of Third Military Medical University(第三军医大学学报), 2003, 25(11): 965-967.
[20] Wei R, Wong JPC, Kwok HF.Osteopontin - a promising biomarker for cancer therapy[J]. Journal of Cancer, 2017, 8(12): 2173-2183.
[21] Li TQ, Teng YL, Zou YG, et al.The highly expressed secreted phosphoprotein 1 gene in prostate cancer metastasis: a microarray-based bioinformatics analysis[J]. National Journal of Andrology(中华男科学杂志), 2014, 20(11): 984-990.
[22] Zhong JQ, Wang YT, Chen YM, et al.Expression and significance of osteopontin in lung cancer[J]. Chongqing Medicine(重庆医学), 2019, 48(10): 118-120.
[23] Gong FH, Yang B, Sun SH, et al.Study on the expression difference of SPP1 in different CRC cell lines and the regulation mechanism of EMT[J]. Journal of Ningxia Medical University(宁夏医科大学学报), 2019, 41(6): 584-588.
[24] Wan XJ, Yi ZH, Fang YR, et al.Association study between BTRK2 gene polymorphisms and schizophrenia in Chinese Han people[J]. General Psychiatry(上海精神医学), 2008, 20(2): 72-74,81.
[25] Liang XY, Ma SJ, Wang Y, et al.The expressions of Runx2 and OPN protein inhuman breast cancer tissue and their association with microcalcofication[J]. Journal of Xi'an Jiaotong University(Medical Sciences)(西安交通大学学报(医学版)), 2014(6): 828-831.
[26] Lin MZ, Wang HD, Wu N, et al.The expression and clinical significance of CXCR3 in human breast cancer[J]. Acta Academiae Medicinae Weifang(潍坊医学院学报), 2014(5): 327-329.
[27] Chen YB, Lin Z.The relationship between the expression of intercellular adhesion molecule (ICAM) and its invasion and metastasis in breast cancer[J]. Chinese Geriatrics, 1998, 18(4): 215-216.
[28] Pan LZ, Yan ZY, Zuo CY, et al.Influence of long-term usage of diazepam on neuroactive ligand-receptor interaction signaling pathway[J]. Journal of China Pharmaceutical University(中国药科大学学报), 2011, 42(5): 443-446.
[29] Pan XQ, Peng C.Research progress on neurotoxicity of radix aconiti lateralis preaparta[J]. World Chinese Medicine(世界中医药), 2017, 12(11): 2551-2554, 2562.

生物信息技术预警乌头类中药抗乳腺癌用药风险

Early Warning of Aconitum Herbs in Breast Cancer Therapy by Bibliometric and Bioinformatics

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