长期使用质子泵抑制剂致药源性显微镜结肠炎1例分析

doi:10.19803/j.1672-8629.2021.02.20

中国药物警戒 ›› 2021, Vol. 18 ›› Issue (2): 194-195.
DOI: 10.19803/j.1672-8629.2021.02.20

长期使用质子泵抑制剂致药源性显微镜结肠炎1例分析

孔彬¹, 林荣芳², 刘晓霞^1,*

¹新疆生产建设兵团医院,新疆乌鲁木齐 830002;
²福建医科大学附属第一医院,福建福州 350001

收稿日期:2019-11-25 修回日期:2021-02-26 出版日期:2021-02-15 发布日期:2021-02-26
通讯作者: ^*刘晓霞,女,本科,副主任药师,临床药学及质控管理。E-mail: 806614739@qq.com
作者简介:孔彬,女,硕士,主管药师,临床药学及药物分析。

Case Analysis of Drug-induced Microscopic Colitis due to Long-term Use of Proton Pump Inhibitor

KONG Bin¹, LIN Rongfang², LIU Xiaoxia^1,*

¹The Xinjiang Production and Construction Corps Hospital, Urumqi Xinjiang 830002, China;
²The First Affiliated Hospital of Fujian Medical University, Fuzhou Fujian 350001, China

Received:2019-11-25 Revised:2021-02-26 Online:2021-02-15 Published:2021-02-26

摘要/Abstract

摘要： 目的对1例长期服用质子泵抑制剂（PPI）治疗慢性腹泻,经病理组织学检查确诊为药源性显微镜结肠炎的罕见病例诊疗过程进行分析。方法查阅文献,并通过分析讨论药源性显微镜结肠炎的特点及PPI致药源性显微镜结肠炎的机制,对该病例中的药品不良反应进行判断和分析。结果不规律长期使用PPI很可能导致药源性显微镜结肠炎。结论临床药师利用药学专业知识及时发现临床诊疗中由于药品引起的不良反应,能为临床诊疗提供帮助,并为PPI在临床合理使用提供参考。

关键词: 显微镜结肠炎, 质子泵抑制剂, 药品不良反应

Abstract: Objective To analyze the process of diagnosing and treating a rare case of microscopic colitis detected during histopathological examination of a patient with chronic diarrhea, who had long been taking a proton pump inhibitor (PPI). Methods Related literature was reviewed while the characteristics of drug-induced microscopic colitis and the mechanism of PPI-induced microscopic colitis were analyzed to determine the adverse drug reactions in this case. Results Irregular and long-term use of a PPI was likely to lead to drug-induced microscopic colitis. Conclusion Clinical pharmacists ought to use their knowledge of pharmacy to quickly discover the adverse reactions caused by drugs in clinical diagnosis and treatment, which can provide reference for the rational use of PPIs in clinical practice.

Key words: drug-induced microscopic colitis, proton pump inhibitor, adverse drug reactions

中图分类号:

R969.3

孔彬, 林荣芳, 刘晓霞. 长期使用质子泵抑制剂致药源性显微镜结肠炎1例分析[J]. 中国药物警戒, 2021, 18(2): 194-195.

KONG Bin, LIN Rongfang, LIU Xiaoxia. Case Analysis of Drug-induced Microscopic Colitis due to Long-term Use of Proton Pump Inhibitor[J]. Chinese Journal of Pharmacovigilance, 2021, 18(2): 194-195.

参考文献

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长期使用质子泵抑制剂致药源性显微镜结肠炎1例分析

Case Analysis of Drug-induced Microscopic Colitis due to Long-term Use of Proton Pump Inhibitor

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