中国药物警戒 ›› 2021, Vol. 18 ›› Issue (1): 30-37.
DOI: 10.19803/j.1672-8629.2021.01.06

• 基础与临床研究 • 上一篇    下一篇

生物信息学技术预警番泻叶用于乳腺癌便秘患者的用药风险

毛秋月1, 林志健1,2, 王雨1, 张冰1,2,*, 萨翼3,*   

  1. 1北京中医药大学中药学院,北京 100029;
    2北京中医药大学中药药物警戒与合理用药研究中心,北京 100029;
    3国家市场监督管理总局食品审评中心,北京 100820
  • 收稿日期:2020-05-17 修回日期:2021-01-18 出版日期:2021-01-15 发布日期:2021-01-18
  • 通讯作者: *张冰,女,教授,主任医师·博导,中药防治代谢性疾病研究,中药药物警戒与合理用药。
  • 作者简介:毛秋月,女,在读硕士,中药防治代谢性疾病研究,中药药物警戒与合理用药。
  • 基金资助:
    国家自然科学基金(81874349):辛热类有毒中药风险-效益阈与效毒机制研究; 国家市场监督管理总局食品审评中心课题:基于长期食用安全风险的蒽醌类成分保健食品上市后人群食用情况评价及对策研究

Early Warning of Risks of Sennae Folium to Constipation Patients with Breast Cancer by Bioinformatics

MAO Qiuyue1, LIN Zhijian1,2, WANG Yu1, ZHANG Bing1,2,*, SA Yi3,*   

  1. 1Beijing University of Chinese Medicine,Beijing 100029,China;
    2Center for Pharmacovigilance and Rational Use of Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China;
    3Center for Food Evaluation,State Administration for Market Regulation,Beijing 100820,China
  • Received:2020-05-17 Revised:2021-01-18 Online:2021-01-15 Published:2021-01-18

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摘要： 目的 基于生物信息学技术,探讨番泻叶对于乳腺癌便秘患者的可能作用机制及潜在不良反应,预警相关用药风险,为临床合理用药研究提供参考。方法 采用生物信息学技术,从高通量基因表达数据库中下载基因表达谱数据芯片GSE85871,筛选番泻叶泻下主要成分番泻苷A干预人乳腺癌细胞MCF7后的差异表达基因,并对其进行基因本体论数据库功能注释、京都基因与基因组百科全书数据库通路富集分析、蛋白网络互作分析。结果 番泻叶应用于乳腺癌便秘患者时可能导致结肠黑变病,伴随中枢性食欲减弱及细胞间信息传递、糖代谢、炎症反应、心肌收缩和情绪异常,可能影响乳腺癌的发生与发展。结论 应用番泻叶时应密切关注该类患者的消化、神经、免疫、心血管系统及糖代谢相关机体状态,并在使用过程中持续关注患者原患疾病乳腺癌的发展情况。

关键词: 番泻叶, 番泻苷A, MCF7, 风险预警, 生物信息学技术

Abstract: Objective To explore the potential adverse reactions of Sennae Folium in constipation patients with breast cancer based on the bioinformatics and warn the risks so as to provide reference for the research on rational use of drugs in constipation patients with breast cancer.Methods of bioinformatics were employed.The microarray data of GSE85871 was downloaded from GEO database,and analyzed by means of gene ontology annotation,Kyoto Encyclopedia of Genes and Genomes pathway analysis and protein-protein interaction networks.Results The analysis showed that when used in constipation patients with breast cancer,Sennae Folium might lead to melanosis coli,along with abnormalities of appetite,cell signaling,carbohydrate metabolism,inflammatory response,myocardial contraction and mood,thus affecting the development of breast cancer.Conclusion It is recommended that close attention should be paid to the body state of patients related to digestive,nervous,immune,cardiovascular systems and carbohydrate metabolism.Clinicians should keep track of the development of patients' preexisting disease.

Key words: Sennae Folium, sennoside A, MCF7, early warning of risks, bioinformatics technology

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