One case of acute transient depression caused by clarithromycin

doi:10.19803/j.1672-8629.20230698

Abstract

Abstract: Objective To analyze the adverse reactions-acute transient depression-caused by a quadruple anti-Helicobacter pylori regimen, and to provide reference for early detection and prompt clinical interventions in such cases. Methods Analysis was made of the clinical data on a 29-year-old female patient who underwent a quadruple regimen (amoxicillin, clarithromycin, pantoprazole, and bismuth potassium citrate) because of acute transient depression caused by Helicobacter pylori infection. Results The transient acute depression was considered to have been triggered by the combined use of four anti-Helicobacter pylori drugs. Evidence-based medicine suggested that clarithromycin was the drug most likely to induce acute transient depression. Conclusion Healthcare providers should vigilantly observe patients for emotional fluctuations during the administration of pharmaceutical interventions for the complete eradication of H. pylori infection. In the event of acute transient depression, it is imperative to promptly discontinue the medication to forestall the worsening of symptoms.

Key words: clarithromycin, amoxicillin, pantoprazole, bismuth potassium citrate, helicobacter pylori, depression, adverse drug reactions

CLC Number:

R975
R994.1

YANG Xueting, HE Bo, YAN Hongli, LI Dongmei. One case of acute transient depression caused by clarithromycin[J]. Chinese Journal of Pharmacovigilance, 2024, 21(3): 352-354.

Add to citation manager EndNote|Ris|BibTeX

URL: https://www.zgywjj.com/EN/10.19803/j.1672-8629.20230698

https://www.zgywjj.com/EN/Y2024/V21/I3/352

References

[1] SHARNDAMA HC, MBA IE.Helicobacter pylori: an up-to-date overview on the virulence and pathogenesis mechanisms[J]. Braz J Microbiol, 2022, 53(1):33-50.
[2] XU W, XU L, XU C.Relationship between helicobacter pylori infection and gastrointestinal microecology[J]. Front Cell Infect Microbiol, 2022, 18(12):938608.
[3] NEUFELD NH, MOHAMED NS, GRUJICH N, et al.Acute neuropsychiatric symptoms associated with antibiotic treatment of helicobacter pylori infections: a review[J]. J Psychiatr Pract, 2017, 23(1): 25-35.
[4] LIOU JM, MALFERTHEINER P, LEE YC, et al.Asian Pacific Alliance on Helicobacter and Microbiota (APAHAM). Screening and eradication of Helicobacter pylori for gastric cancer prevention: the Taipei global consensus[J]. Gut, 2020, 69(12):2093-2112.
[5] NYSSEN OP, PEREZ-AISA A, TEPES B, et al.Adverse event profile during the treatment of helicobacter pylori: a real-world experience of 22 000 patients from the European Registry on H. pylori management (Hp-EuReg)[J]. Am J Gastroenterol, 2021, 116(6):1220-1229.
[6] National Institute for Health and Care Excellence (NICE).Depression in adults: treatment and management[EB/OL].(2022-06-29)[2023-11-29].https://www.nice.org.uk/guidance/ng222/resources/depression-in-adults-treatment-and-management.
[7] TSAI CF, CHEN MH, WANG YP, et al.Increased risk of short-term depressive disorder after Helicobacter pylori eradication: a population-based nested cohort study[J]. Helicobacter, 2021, 26(4): e12824.
[8] LAUDISIO A, ANTONELLI INCALZI R, GEMMA A, et al.Use of proton-pump inhibitors is associated with depression: a population-based study[J]. Int Psychogeriatr, 2018, 30(1):153-159.
[9] NOVOTNY M, KLIMOVA B, VALIS M, et al.Ppi long term use: risk of neurological adverse events?[J]. Front Neurol, 2018, 9: 1142.
[10] LIANG N, ZHOU S, LI T, et al.Physiologically based pharmacokinetic modeling to assess the drug-drug interactions of anaprazole with clarithromycin and amoxicillin in patients undergoing eradication therapy of H. pylori infection[J]. Eur J Pharm Sci, 2023, 189:106534.
[11] WONG AY, WONG IC, CHUI CS, et al.Association between acute neuropsychiatric events and helicobacter pylori therapy containing clarithromycin[J]. JAMA Intern Med, 2016, 176(6): 828-834.
[12] LIU JJ, WANG YL, WANG T, et al.Analysis of one case of delayed anaphylaxis induced by clarithromycin tablets[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2020, 17(12): 946-948.
[13] WEN J, CHENYANG, ZHAO M, et al.Effects of clarithromycin on the pharmacokinetics of tacrolimus and expression of CYP3A4 and P-glycoprotein in rats[J]. Fundam Clin Pharmacol, 2023, 37(4): 843-848.
[14] NAU R, SEELE J, DJUKIC M, et al.Pharmacokinetics and pharmacodynamics of antibiotics in central nervous system infections[J]. Curr Opin Infect Dis, 2018, 31(1): 57-68.
[15] LEGENDRE T, BOUDEBESSE C, HENRY C, et al.Antibiomania: Think of the manic syndrome secondary to antibiotic therapy[J]. Encephale, 2017, 43(2): 183-186.
[16] LU Y, LIU BP, TAN CT, et al.Lifetime pathogen burden, inflammatory markers, and depression in community-dwelling older adults[J]. Brain Behav Immun, 2022, 102: 124-134.
[17] BARAL KC, BAJRACHARYA R, LEE SH, et al.Advancements in the pharmaceutical applications of probiotics: dosage forms and formulation technology[J]. Int J Nanomedicine, 2021, 12(16): 7535-7556.