Heavy metal residual and related elemental species in Polygonum cillinerve (Nakai) Ohwl

doi:10.19803/j.1672-8629.20230345

Abstract

Abstract: Objective To explore the residual levels of heavy metals in Polygonum cillinerve (Nakai) Ohwl and the existing arsenic species. Methods Using microwave digestion method combined with inductively coupled plasma mass spectrometry (ICP-MS) method, Pb (lead), Cd (cadmium), As (arsenic), Hg (mercury), Cu (copper) five heavy metals and related elements in Polygonum cillinerve (Nakai) Ohwl Measure were detected, and the content levels were analyzed; in addition, using high performance liquid phase coupled with inductively coupled plasma mass spectrometry (HPLC-ICP-MS), monomethyl arsenic (MMA), dimethyl arsenic (DMA), and arsenous acid (AsIII), arsenic acid (AsV), arsenic betaine (AsB), arsenic choline (AsC) and other six known arsenic species were studied. Results The results of the study showed that according to the 2020 edition of the Chinese Pharmacopoeia for botanical limits, except one batch of Cd in 10 batches of Polygonum cillinerve (Nakai) Ohwl, and other elements did not exceed the limit, and the overall pass rate was high. The HPLC-ICP-MS research results showed that, except for the trace amount of AsV detected in the first batch of Polygonum cillinerve (Nakai) Ohwl, the inorganic arsenic and organic arsenic in the other batches of Polygonum cillinerve (Nakai) Ohwl were not detected. Conclusion This study showed the safety risks of heavy metals and related elements in Polygonum cillinerve (Nakai) Ohwl are low. This research provides data support for the formulation of the limit standards for Polygonum cillinerve (Nakai) Ohwl heavy metals and related elements. At the same time, the determination of element species will help to accurately evaluate the safety risks brought by related elements in the future.

Key words: Polygonum cillinerve (Nakai) Ohwl, heavy metals, related elements, ICP-MS, arsenic, morphology, valence, residual

CLC Number:

R973
R994.1

LI Yaolei, WANG Zhao, LI Hailiang, ZAN Ke, JIN Hongyu, MA Shuangcheng. Heavy metal residual and related elemental species in Polygonum cillinerve (Nakai) Ohwl[J]. Chinese Journal of Pharmacovigilance, 2023, 20(11): 1234-1237.

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