Abstract: Objective To analyze the causes of luminous phenomena in a patient under combined medication, recommend therapies, and make physicians and pharmacists better aware of the luminous phenomena and drug interactions. Methods One patient with acute myocardial infarction developed sinus tachycardia and ventricular arrhythmia. During the treatment with a variety of antiarrhythmic drugs, luminous phenomena occurred for a short time. The pharmacist assisted the clinician in analyzing the causes of adverse reactions and recommended treatments. Results The clinical pharmacist clarified the mechanism by which luminous phenomena was caused by irvabradine. The occurrence of luminous phenomena was attributed to drug interactions. The drug dose was adjusted and the patient was soothed at the same time. Conclusion Active participation of clinical pharmacists in pharmaceutical care will help to detect adverse drug reactions as soon as possible so as to prevent irrational use of drugs.

Key words: amiodarone, irvabradine, adverse drug reaction, drug interactions, luminous phenomena