Correlations of ABCB1 C3435T genetic polymorphism with serum concentrations and adverse reactions of high-dose methotrexate in children with mature B-cell lymphoma

doi:10.19803/j.1672-8629.20220680

Abstract

Abstract: Objective To investigate the correlations between polymorphisms of ABCB1 C3435T genes（CC, CT and TT）, blood drug concentrations and adverse drug reactions (ADR) during high-dose methotrexate (HD-MTX) chemotherapy in children with mature B-cell lymphoma. Methods The medical data of children with mature B-cell lymphoma who had received HD-MTX chemotherapy and had had their MTX concentrations after administration determined and polymorphisms of ABCB1 C3435T detected was retrospectively collected from Oct, 2019 to Oct, 2022. The relationships between ABCB1 C3435T gene polymorphisms, MTX plasma concentrations and ADR were analyzed. Results A total of 66 patients, including 52 males and 14 females with an average age of 7.46±3.09 years (1.9~15.0 years), were enrolled. The most common ADR associated with HD-MTX were neutropenia (98.48%), anemia (89.39%), thrombocytopenia (77.27%) and mucosal injury (53.03%). The MTX 44 h blood concentration of the ABCB1 C3435T TT type was higher than that of the CC type (P<0.05). Compared with the ABCB1 C3435T CC type, CT and TT types had higher incidence of mucosal injury, vomiting and liver function damage (P<0.05). Conclusion ABCB1 C3435T gene polymorphisms may be associated with serum levels of HD-MTX and adverse reactions (mucosal injury, vomiting and liver function damage) in children with mature B-cell lymphoma.

Key words: ABCB1 C3435T genetic polymorphism, high-dose methotrexate, adverse drug reaction, mature B-cell lymphoma, pediatric

CLC Number:

R994.11

LUO Fangmei, WU Pan, LI Jing, WANG Ting, WANG Fangjie. Correlations of ABCB1 C3435T genetic polymorphism with serum concentrations and adverse reactions of high-dose methotrexate in children with mature B-cell lymphoma[J]. Chinese Journal of Pharmacovigilance, 2023, 20(6): 675-679.

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