Efficacy and safety of compound salvia miltiorrhiza spray/aerosol for angina pectoris due to coronary artery disease: a Meta analysis

doi:10.19803/j.1672-8629.20211052

Abstract

Abstract: Objective To evaluate the efficacy and safety of compound salvia spray/aerosol in the treatment of angina pectoris due to coronary artery disease. Methods Eight databases including CNKI, Wanfang Data, VIP, SinoMed, Cochrane Library, PubMed, Embase, and Web of Science were searched for related data that was published from inception to May 5, 2021. Randomized controlled trials of compound salvia spray/aerosol in the treatment of angina pectoris due to coronary artery disease were screened for meta-analysis. TSA software was used to predict the sample size of the outcome indicators. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) was used to evaluate the quality of the included outcome indicators. Results A total of 9 studies were included, with a total sample size of 1 113 cases, 702 of which were in the trial group and 411 in the control group. The results of Meta-analysis showed that the therapeutic effect of compound salvia spray/aerosol alone was better than that of compound salvia tablets. Compared with nitrate drugs alone, the combination of nitrate drugs was not significantly different in terms of therapeutic effect against angina pectoris due to coronary artery disease, the effective rate of ECG or the incidence of adverse drug reactions. However, it was superior to nitrate drugs alone in the stabilization of plaques. The main adverse reaction was nasopharyngeal discomfort, which could resolve itself, and no serious adverse reactions occurred. Conclusion Compound salvia spray/aerosol is highly effective and safe in the treatment of angina pectoris due to coronary artery disease.

Key words: compound salvia miltiorrhiza spray/aerosol, angina pectoris, randomized controlled trial, nitrate drugs, systematic review, Meta-analysis, GRADE assessment, adverse drug reaction

CLC Number:

R994.11

CHENG Fengjingming, LYU Jian, XIE Yanming. Efficacy and safety of compound salvia miltiorrhiza spray/aerosol for angina pectoris due to coronary artery disease: a Meta analysis[J]. Chinese Journal of Pharmacovigilance, 2023, 20(5): 536-543.

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