Characteristics of Psoralea corylifolia induced liver injury

doi:10.19803/j.1672-8629.20220167

Abstract

Abstract: Objective To analyze the characteristics, risk factors and prognosis of liver injury caused by Psoralea corylifolia so as to provide data for rational drug use. Methods The literature about liver injury caused by Psoralea corylifolia or its related preparations that was published between 1962 and 2021 was searched for. The literature was screened before the related data was statistically analyzed. Results A total of 47 articles were retrieved from the databases, involving 55 cases. The incidence of the disease was higher among females, and most of the patients raged from 21 to 60 in age, mainly due to unprocessed Psoralea corylifolia. Clinical medications lasted more than 30 days. Patients who had a previous history of liver disease or used drugs that caused liver injury were more vulnerable to severe and fatal liver injury. Liver injury caused by Psoraleae corylifolia was dominated by liver cell injury, accounting for nearly 90%, and most of the cases were acute liver injury. Symptoms were likely to improve via active treatment after drug withdrawal, and the prognosis was good. Conclusion Women, elders and patients with liver disease history and previous liver injury induced by Psoraleae corylifolia should not take any Psoraleae corylifolia or its preparations in order to prevent fatal reactivation. Liver function should be monitored during clinical use of Psoralea corylifolia. Drugs should be withdrawn in case of abnormality.

Key words: Psoralea corylifolia, drug-induced liver injury, literature analysis, characteristics analysis, RUCAM analysis

CLC Number:

R932
R994.11

CHEN Chao, ZHU Lan, LIU Lihong, HAN Jiayin, ZHU Yan. Characteristics of Psoralea corylifolia induced liver injury[J]. Chinese Journal of Pharmacovigilance, 2023, 20(4): 449-453.

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