The drug combination of Danshen Ligustrazine injection in the real world

doi:10.19803/j.1672-8629.2022.08.08

Abstract

Abstract: Objective To summarize the category of combined medication of Danshen Ligustrazine injection in the real world so as to provide reference for clinical use. Methods The category of Chinese medicine and western medicine in 38 126 patients treated with Danshen Ligustrazine Injection from 24 tertiary first-class hospitals in China from February 10, 2010 to June 19, 2019 were analyzed. Results The top three categories of the two Chinese medicines that were most commonly used in combination were listed: clearing heat and detoxifying agent combined with promoting blood circulation. Blood stasis removing agent, nourishing agent combined with activating blood and removing blood stasis agent, anti-surface agent combined with promoting blood circulation and removing stasis agent. The top three categories of the three Chinese medicines that of were listed: expectorant combined with external-relieving agent and blood-activating and stasis-removing agent, expectorant Combine heat-clearing and detoxifying agent with blood-activating and stasis-removing agent. The top three categories of the two western medicines that were most commonly used in combination were listed: anticoagulant thrombolysis and antiplatelet drugs combined with antibiotics, acid suppressants combined with antibiotics, electrolyte balance regulators combined with antibiotics; the most commonly used combined drugs. The top three categories of the three western medicines that of were listed: acid-suppressing drugs combined with anticoagulation and thrombolysis, antiplatelet drugs and antibiotics, electrolyte balance regulators combined with anticoagulant thrombolysis and antiplatelet drugs and antibiotics, acid-suppressing drugs Combined electrolyte balance regulators and antibiotics. Conclusion Danshen Ligustrazine injection has many types of combined drugs in clinical practice. Clinicians should be alert to adverse drug reactions caused by drug-drug interactions in clinical practice

Key words: Salvia Miltiorrhiza injection, real world, hospital information systom(HIS), the category of combined medication

CLC Number:

R969

ZHANG Hongwei, LI Yuanyuan, XIE Yanming, MA Xiaochang, WANG Lianxin, WEI Ruili, SUN Linxi, XU Hongyan, ZHUANG Yan. The drug combination of Danshen Ligustrazine injection in the real world[J]. Chinese Journal of Pharmacovigilance, 2022, 19(8): 851-856.

References

[1] China Cardiovascular Health and Disease Report Writing Group. Summary of china cardiovascular health and disease report 2019[J]. Chinese Circulation Journal(中国循环杂志), 2020, 35(9): 833-854.
[2] Stroke Prevention and Control Engineering Committee of the National Health and Family Planning Commission. Guidelines for the Rational Use of Chinese Patent Medicines for Ischemic Stroke in China[EB/OL]. (2019-04-25)[2022-02-01]. http://www.cnstroke.com/NewsInfo/News/PDFPreview?path=/upload /file/20170620/6363356817791319784108498.pdf,2017-5-20/2019-3-10.
[3] Chinese Medical Doctor Association Integrative Medicine Physician Branch, Chinese Integrative Medicine Association Cardiovascular Disease Professional Committee, Chinese Integrative Medicine Association Critical Care Professional Committee, et al. Expert consensus on the diagnosis and treatment of acute myocardial infarction with integrated traditional Chinese and Western medicine[J]. Chinese Journal of Integrated Traditional and Western Medicine(中国中西医结合杂志), 2014, 34(4): 389-395.
[4] GAO Y, WANG GQ, WANG J.Expert consensus statement on Danshen Chuanxiongqin Injection in clinical practice[J]. China Journal of Chinese Materia Medica(中国中药杂志), 2019, 44(14): 2937-2942.
[5] ZHANG HW, XIE YM, GAO Y, et al.Study on characteristics of clinical symptoms and combined use of Danshen Ligustrazine Injection in The Real World[J]. Chinese Archives of Traditional Chinese Medicine(中华中医药学刊), 2021, 39(6): 55-60.
[6] National Pharmacopoeia Committee.Pharmacopoeia of the people's Republic of China(中华人民共和国药典)[M]. Beijing: China Medical Science Press, 2015.
[7] Ministery of Human Resources and Social Security. Notice on printing and distributing the catalogue of Medicine List for National Basic Medical Insurance,Employment Injury Insurance and Maternity Insurance (2017 Edition)[EB/OL]. (2017-02-21)[2022-02-01].http://www.mohrss.gov.cn/SYrlzyhshbzb/dongtaixinwen/buneiyaowen/201702/t20170223_266787.html.
[8] WHO. WHO Collaborating Centre for Drug Statistics Methodology.Guidelines for ATC classification and DDD assignment 2011[EB/OL].[2022-02-01]. http://www.whocc.no.
[9] HUANG JQ, ZHANG X, ZHENG YJ, et al.Analysis of monitoring results of Baiyun District in 2013 events of cardiovascular and cerebrovascular disease in Guangzhou city[J]. Henan Journal of Preventive Medicine(河南预防医学杂志), 2015, 26(2): 163-166.
[10] ZHANG XF, ZHAO X, LI XL, et al.The protective efficacy of estrogen on cardiovascular system in female patients with hypertension in different menopause duration[J]. Chinese Journal of Arteriosclerosis(中国动脉硬化杂志), 2017, 25(2): 175-180.
[11] MENG Q, LI Y, JI T, et al.Estrogen prevent atherosclerosis by attenuating endothelial cell pyroptosis via activation of estrogen receptor α-mediated autophagy[J]. J Adv Res,2020, 28: 149-164.
[12] XU Z, LIU Y, LIANG F.Clinical efficacy of Danshen Chuanxiongqin injection and its effect on serum levels of LPA, Hcy and MCP-1 in patients with ischemic stroke[J]. Journal of Changchun University of Chinese Medicine(长春中医药大学学报), 2021, 37(1): 84-87.
[13] LIU JZ, WANG T, ZHAO YG, et al.Efficacy of Danshen Ligustrazine injection on elderly patients with unstable angina pectoris and its effect on serum hs-CRP and blood lipids[J]. Pharmacology and Clinics of Chinese Materia Medica(中药药理与临床), 2015,31(4): 237-239.
[14] SUI YB, SUN BH, ZHANG DD, et al.Clinical study of Danshen Ligustrazine injection on patients with chronic heart failure and blood stasis syndrome[J]. Journal of Emergency in Traditional Chinese Medicine(中国中医急症), 2020, 29(5): 806-809.
[15] OUYANG YJ, ZHANG YM, YAN D.Observation of curative effect of Danshen Ligustrazine injection combined with western medicine in the treatment of acute pancreatitis[J]. Journal of Emergency in Traditi-onal Chinese Medicine(中国中医急症). 2012, 21(4): 644-645.
[16] ZHANG ZJ, XIAO XL.Study on the curative effect of radix salivae miltiorrhizae and ligustrazine combined with Xueshuantong in the treatment of cerebral infarction and its influence on hemodynamics[J].Chinese Journal of Modern Drug Application(中国现代药物应用), 2020, 14(7): 15-17.
[17] ZOU LQ, LI YL.Research progess of heart diseases from aspect of stasis─toxin[J]. Acta Chinese Medicine and Pharmacology(中医药学报), 2018, 46(3): 125-129.
[18] SHEN PY,CHEN SM,XIONG YQ.Analysis of TCM etiology and pathogenesis of acute cerebral infarction[J]. Jiangxi Journal of Traditional Chinese Medicine(江西中医药). 2017, 48(5): 7-9.
[19] XIE LD, CHEN LX, WU SX,et al.An overview of clinical and basic research on Simiao Yong'an decoction in the treatment of coronary heart disease[J]. Global Traditional Chinese Medicine(环球中医药), 2012, 5(8): 629-633.
[20] DU ZG, JIANG HY.Observation of curative effect of modified Simiao Yong'an decoction on carotid atherosclerotic plaque in patients with cerebral infarction[J].Liaoning Journal of Traditional Chinese Medicine(辽宁中医杂志), 2008, 35(3): 393-394.
[21] MEI Q, ZENG XF.Study on the distribution of complex syndrome groups of 976 cases of coronary heart disease in traditional Chinese medicine[J]. Journal of Basic Chinese Medicine(中国中医基础医学杂志). 2019, 25(10): 1370-1372.
[22] LI SP, CHEN QG, ZHANG JP, et al.Study on syndrome differentiation of acute cerebral infarction[J]. Jiangsu Journal of Traditional Chinese Medicine(江苏中医药), 2004, 25(1): 14-16.
[23] ZHANG H, WEI ZY, HUO Q.The position of Qi deficiency and blood stasis in cardiovascular and cerebrovascular diseases and aging mechanism[J]. Journal of Shandong University of Traditional Chinese Medicine(山东中医学院学报),1996, 2: 107-108.
[24] LIU Y, YOU K.Observation of curative effect of modified Bazhen decoction combined with western medicine in the treatment of unstable angina pectoris of coronary heart disease[J]. Journal of Practical Traditional Chinese Medicine(实用中医药杂志), 2016, 32(3): 233-234.
[25] ZHANG HZ, LIU JC, WANG Q, et al.Effect of buyang huanwu decoction drug - containing serum on rho kinase and expressions of tfmrna, matrix metalloproteinase mmp - 2mrna and mmp-9mrna in vascular smooth muscle cells[J]. Chinese Archives of Traditional Chinese Medicine(中华中医药学刊), 2021, 39(1): 17-21.
[26] GENG YL.Efficacy observation of Huangqi Buxue Decoction combined with Danshen Ligustrazine injection in the treatment of elderly patients with H-type hypertension complicated with acute cerebral infarction[J]. Journal of Clinical Medicine in Practice(实用临床医药杂志), 2020, 15: 28-31.
[27] WANG W, JIANG B, SUN H, et al.Prevalence, incidence, and mortality of stroke in China: results from a nationwide population-based survey of 480 687 adults[J]. Circulation. 2017, 135(8): 759-771.
[28] ZHANG J, JIANG LD.On the Characteristics of TCM syndrome and treatment of senile exogenous diseases[J]. Modern Chinese Clinical Medicine(现代中医临床), 2006, 13(5): 37-38.
[29] SUN FR, CHEN XZ, SUN YF, et al.Correlation between upperrespiratory tract infection in influenza-prone season and cardiovascular events in patients with coronary heart disease[J]. Chinese Journal of Nosocomiology(中华医院感染学杂志), 2018, 28(23): 3527-3531.
[30] TIAN L.Clinical characteristics and risk factors of nosocomial infection in hospitalized patients with acute cerebral infarction[J]. Chinese Journal of Practical Nervous Diseases(中国实用神经疾病杂志), 2016, 19(2): 75-76.
[31] YANG DH, SONG DX, XI QC, et al.Clinical study on Shufeng Jiedu capsules combined with salviae miltiorrhizae and Ligustrazine hydrochloride injection in treatment of acute exacerbation of chronic obstructive pulmonary disease[J]. Drugs & Clinic(现代药物与临床), 2017, 32(7): 1264-1268.
[32] GAO CY, WU CH, ZHAO JG, et al.Guidelines for diagnosis and treatment of cerebral infarction in China (2017)[J]. Chinese Journal of Integrated Traditional and Western Medicine(中国中西医结合杂志). 2018, 38(2): 136-144.
[33] CHEN KJ, ZHANG MZ, HUO Y.Expert consensus of integrative Chinese and Western Medicine for acute myocardial infarction[J]. Chinese Journal of Integrated Traditional and Western Medicine(中国中西医结合杂志), 2014, 34(4): 389-395.
[34] ZHOU H, MA ZDN, ZHOU DS, et al.Study on correlation between TCM constitution and risk factors in 303 patients with acute cerebral infarction[J]. Journal of Hunan University of Chinese Medicine(湖南中医药大学学报), 2020, 40(1): 54-58.
[35] XIE TT, WEI Y, JIANG LH.Research progress on constitution of traditional Chinese medicine in coronary heart disease[J]. Journal of Basic Chinese Medicine(中国中医基础医学杂志), 2020, 26(10): 156-159.
[36] HU W, TANG Y.Brief analysis on relationship between phlegm-dampness constitution and hyperlipidemia[J]. Tianjin Journal of Traditional Chinese Medicine(天津中医药), 2011, 28(3): 221-223.
[37] MENG QK, WANG PH, WANG L, et al.Clinical observation on 50 cases of hyperlipidemia treated by erchen decoction[J].Pharmacology and Clinics of Chinese Materia Medica(中药药理与临床), 2007, 23(6): 75-76.
[38] JIANG ZH, WANG ME, CAO YK, et al.Characteristics and risk factors for nosocomial infection in patients with cerebral infarction[J]. Chinese Journal of Nosocomiology(中华医院感染学杂志). 2020, 30(21): 3283-3287.
[39] LIAO Q, LI B, LAI CY.Incidence of lower respiratory tract infection and its influence on cardiovascular events in the elderly patients with coronary heart disease[J]. Chinese Journal of Multiple Organ Diseases in the Elderly(中华老年多器官疾病杂志), 2019, 18(6): 443-446.
[40] WOODHEAD M.New guidelines for the management of adult lower respiratory tract infections[J]. Eur Respir J, 2011, 38(6): 1250-1251.
[41] Expert Committee on Rational Drug Use of National Health and Family Planning Commission, Chinese Pharmacists Association. Guidelines for Rational Drug Use for Coronary Heart Disease (2nd Edition)[J]. Chinese Journal of the Frontiers of Medical Science(Electronic Version)(中国医学前沿杂志(电子版)), 2018, 10(6): 7-136.
[42] Chinese Society of Neurology, Chinese Stroke Society. Chinese guidelines for diagnosis and treatment of acute ischemic stroke 2018[J]. Chinese Journal of Neurology(中华神经科杂志), 2018, 51(9): 666-682.
[43] GUO XC, GAO Y, XIE YM, et al.Study on clinical characteristics of Danshen Chuanxiongqin injection in treatment of cerebral infarction in real world[J]. China Journal of Chinese Materia Medica(中国中药杂志), 2020, 45(14): 3307-3315.
[44] CHEN J, TAN DM, MENG ZF.Effects of Danshen Ligustrazine injection combined with dual antiplatelet on cell apoptosis, plaque stability and vascular endothelial function in patients with unstable angina pectoris[J]. Chinese Journal of Gerontology(中国老年学杂志), 2020, 40(12): 2477-2480.
[45] ZU YM.Analysis of 102 cases of antimicrobial adverse reactions[J]. Chinese Journal of Clinical Rational Drug Use(临床合理用药杂志), 2010, 3(6): 45-46.
[46] ZHOU LJ.Analysis of adverse reactions caused by antibiotics and clinical rational drug use[J]. China & Foreign Medical Treatment(中外医疗), 2020, 39(29): 88-90,130.
[47] GUO X, PEI GZ, LU NJ, et al.Signal mining of ADR signals for salviae miltiorrhiza and ligustrazine hydrochloride injection in the real world[J]. Anhui Medical and Pharmaceutical Journal(安徽医药), 2020, 24(2): 421-424.
[48] YAN CG, LAI L.Efficacy observation of esomeprazole combined with Danshen ligustrazine injection in the treatment of senile chronic gastritis[J]. Northwest Pharmaceutical Journal(西北药学杂志), 2009, 24(2): 142-143.
[49] GUO ZQ.Clinical observation of 58 cases of electrolyte disturbance after coronary intervention[J]. Modern Diagnosis and Treatment(现代诊断与治疗), 2016, 27(14): 2681-2683.
[50] HU F, WANG JY.A comparative study of serum K+, Na+, Mg²+, Cl- levels in patients with cerebral infarction in acute stage and convalescent stage[J]. Hainan Medical Journal(海南医学), 2004, 15(10): 63-64.