Abstract: Objective To explore optimized combined medications with Xiyanping injection in the treatment of myocardial damage and myocarditis. Methods Between December 1, 2006 and June 30, 2016, the clinical data on 19 729 patients with myocardial damage and myocarditis treated with Xiyanping injection and combined medications was retrieved from the integrated data warehouse of large hospital information system (HIS) established by the Institute of Clinical Basic Medicine, Chinese Academy of Chinese Medical Sciences. Complex network analysis was performed using the tabu search algorithm. Results Among the included patients with myocardial damage and myocarditis, 84.77% were under 3 years old. As for drug combinations, the most frequently used ones in clinical practice were heat-clearing prescriptions, phlegm-resolving and cough-relieving and asthma-relieving prescriptions, heat-clearing and detoxicating prescriptions, and blood-activating and stasis-resolving ones, with the main effects attributed to “clearing” and “activating” properties. Heat-clearing prescriptions were used most frequently in combined medications with of Xiyanping injection, and there was a close structural relationship between the heat-clearing prescriptions and other Chinese medicines in network analysis. Conclusion It is recommended that the main therapeutic principle be “clearing heat and detoxification, cooling blood and activating blood, as well as nourishing Yin and consolidating Yang”. The flexible compatibility of Chinese medicines with the effects of clearing heat and detoxification, cooling blood and activating blood can be used to improve the health of patients and their life quality after recovery.

Key words: Xiyanping injection, real world, myocardial damage, myocarditis, combination of drugs