Abstract: Objective To analyze the adverse drug reactions (ADR) of ribavirin in order to provide reference for the safety of clinical medications. Methods Adverse reaction reports of ribavirin collected between January 22, 2015 and February 28, 2020 in Changsha were statistically analyzed. Results The clinical manifestations of ADR caused by ribavirin were complicated and diverse, involving 107 patients. Forty-three different clinical manifestations of nine types of ADR were observed in various age groups. The proportion of children and the elderly was higher, and males slightly outnumbered females. Intravenous administration was more common than oral or inhaled administration. The main ADR were systemic damage and damage to the gastrointestinal system. There were 55 cases of severe ADR. ADR occurred within 30 minutes of medication in 69 patients, and most of them were relieved after drug withdrawal or symptomatic treatment. Conclusion Adverse reactions of ribavirin have various clinical manifestations, to which children, the elderly and patients receiving intravenous administration are more vulnerable. Adverse reactions should be closely monitored within 30 minutes of RBV administration.

Key words: ribavirin, adverse drug reaction, special populations, safe medication