257 cases of adverse drug reactions induced by lidocaine hydrochloride injection used in dentistry

doi:10.19803/j.1672-8629.2022.04.16

Abstract

Abstract: Objective To analyze the features of adverse drug reaction(ADR) induced by lidocaine hydrochloride injection used in dentistry in order to provide data for rational use of drugs in clinic. Methods Two hundred and fifty-seven cases of ADR caused by lidocaine hydrochloride injection used in dentistry that were collected from January 1, 2009 to December 31, 2019 in the Shandong provincial ADR monitoring system were analyzed. Results ADR induced by lidocaine hydrochloride injection usually occurred within ten minutes of medication. Multiple systems were affected, including the central system, peripheral nervous system and the cardiovascular system. Conclusion Health care providers should be alert to ADR induced by lidocaine hydrochloride injection used in dentistry. Drug manufacturers should revise and improve the safety information in drug instructions promptly.

Key words: lidocaine hydrochloride, dentistry, adverse drug reaction

CLC Number:

R994.11

MAO Shumin, QIU Jianmin, ZHAO Xifeng, LYU Xinhua. 257 cases of adverse drug reactions induced by lidocaine hydrochloride injection used in dentistry[J]. Chinese Journal of Pharmacovigilance, 2022, 19(4): 417-420.

References

[1] ZHANG M, ZHANG Y, REN SS, et al.Anesthesia effect of infiltration anesthesia and block anesthesia in the treatment for irreversible pulpitis: a meta-analysis[J]. Chinese Journal of Practical Stomatology(中国实用口腔科杂志), 2018, 11(3): 160-166.
[2] National Health Commission. Management measures for reporting and monitoring of adverse drug reaction (division of health) [EB/OL].(2011-05-04)[2020-06-18].http://www.nhc.gov.cn/wjw/bmgz/201105/b442a66fc52b4793a57160002ac2a1a9.shtml.
[3] LIU Z. Analysis of oral health service status in a community health service center in Beijing from2017 to 2018[D]. Beijing: Chinese Centre for Disease Control and Prevention(中国疾病预防控制中心), 2018.
[4] LI FL, MENG JR, GUO Y, et al.The epidemiological features of 1777 patients with impacted mandibular third molar and their effect on dry socket morbidity after tooth extraction[J]. Journal of Practical Stomatology(实用口腔医学杂志), 2019, 35(6): 818-821.
[5] HE W.Investigation on incidence of mandibular third molar impaction and pericoronitis in college students[J]. Health Medicine Research and Practice(保健医学研究与实践), 2013, 10(3): 22-23, 26.
[6] XIE YF.Sex hormone and periodontal disease[J]. International Journal of Stomatology(国际口腔医学杂志), 2003, 30(4): 283-285.
[7] WANG H, ZHAO SD, LIU CL, et al.Literature analysis of adverse drug reactions induced by lidocaine as stomatological medicine[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2012, 9(8): 481-484.
[8] JIANG HQ, KONG XP, WANG F.Statistical analysis of mandibular third molar[J]. Chinese Community Doctors(中国社区医师), 2012, 14(10): 193-194.
[9] National Health Commission. National Health and Family Planning Commission released the results of the fourth national oral health epidemiological survey [EB/OL].(2017-09-19)[2020-08-10]. http://www.nhc.gov.cn/jkj/s5879/201709/9b4d4a4ec1c54723820ddbaed97a6d26.shtml.
[10] XU H, JIN XJ.Research progress of perioperative intravenous lidocaine infusion[J]. Journal of Qiqihar Medical College(齐齐哈尔医学院学报), 2019, 40(22): 2869-2871.
[11] GENG Q, SHEN L.The application of continuous intravenous infusion of lidocaine perioperative in multimodal analgesia and mechanism of action[J]. Clinical Medication Journal(临床药物治疗杂志), 2018, 16(2): 80-83.
[12] LIU SQ, CHENG XX, MA XJ.Effect of adrenaline in local anesthetics on peripheral blood circulation of limbs[J]. Chinese Journal of Aesthetic and Plastic Surgery(中国美容整形外科杂志), 2019, 30(11): 699-700, 714.
[13] LIU Y, YANG JJ, DONG XY, et al.Study on comfortable treatment of mucosal surface anesthesia in extraction of deciduous teeth[J]. Elect-ronic Journal of General Stomatology(全科口腔医学电子杂志), 2019, 6(25): 34-35.
[14] HUA CK.Research on block anesthesia of posterior superior alveolar nerve[J]. International Journal of Stomatology(国际口腔医学杂志), 2019, 46(5): 497-502.
[15] YOU J, LIN QL, HOU ZW.Comparative analysis of the effects of anterior middle superior alveolar nerve block anesthesia and local infiltration anesthesia in treatment of maxillary periodontal disease[J]. Hebei Medical Journal(河北医药), 2018, 40(12): 1820-1822, 1827.
[16] WU WH.Application of anterior and middle superior alveolar nerve block anesthesia in maxillary periodontal treatment[J]. Electronic Journal of General Stomatology(全科口腔医学电子杂志), 2016, 3(17): 82-82, 84.
[17] LI SH, WANG Q.Research progress on anesthesia of mandibular posterior teeth[J]. Journal of Oral Science Research(口腔医学研究), 2012, 28(12): 1313-1316.
[18] ZHANG LN, SUN B.2 cases of lidocaine induced mental disorder[J]. Chinese Journal of Practical Nervous Diseases(中国实用精神疾病杂志), 2006, 9(2): 73.
[19] CHENG YH.Literature analysis on 128 cases of adverse reactions induced by lidocaine[J]. Shanxi Medical Journal(山西医药杂志), 2012, 41(4): 404-405.
[20] TAI SB, ZHOU XM, ZHENG ZJ.One case and literature review of severe allergic reactions induced by lidocaine[J]. Chinese Journal of Clinical Rational Drug Use(临床合理用药杂志), 2019, 12(30): 119-120, 122.
[21] ABABAIKERI·TE X. A preliminary study on the psychology of adverse drug use[J]. Medical Information(医学信息), 2010, 23(9): 3329.
[22] YAN DS, YAN KY, QUAN W, et al.Analysis adverse effects of psychotropic drugs in 101 children and adolescent patients[J]. Journal of Clinical Psychiatry(临床精神医学杂志), 2020, 30(2): 112-114.
[23] XU JQ, ZENG JS.One case of lidocaine anaphylactic shock with disseminated intravascular coagulation[J]. Journal of Prevention and Treatment for Stomatological Diseases(口腔疾病防治), 2003, 11(4): 276.
[24] KONG JC, JI LW.Severe deafness after local anesthesia of lidocaine injection used in oral cavity.[J]. Adverse Drug Reactions Journal(药物不良反应杂志), 2006, 8(6): 451.