Analysis of 283 cases of drug fever

doi:10.19803/j.1672-8629.2022.03.22

Abstract

Abstract: Objective To explore the characteristics of drug fever and provide reference for related diagnosis and treatment. Methods Cases of drug fever reported by health institutions in Enshi Prefecture from January 1, 2015 to December 31, 2019 to the national adverse drug reaction detection system were retrospectively collected. A total of 283 cases were screened and analyzed. Results Seventy-nine of these cases (27.92%) were caused by traditional Chinese medicine, and 64 (22.61%) by antibiotics. The main route of administration was intravenous injection(249 cases, 87.99%). Most of these cases were accompanied by other symptoms, 199 of which were chills (46.28%) and 40 were skin damage (9.30%). Drug fever in most (85.87%) of the cases occurred within 7 days of administration, but it could occur as late as 28 days after administration. 268 of these cases (94.70%) had temperature remission soon after drug withdrawal. Conclusion Traditional Chinese medicine and antibiotics are the drugs mainly responsible for drug fever in Enshi prefecture. Patients with drug fever often have chills, and only a few have such allergic symptoms as skin lesions.

Key words: drug fever, adverse drug reaction, fever

CLC Number:

R969

LIU Juan, ZHANG Jing, YANG Yanling, WANG Yinhui. Analysis of 283 cases of drug fever[J]. Chinese Journal of Pharmacovigilance, 2022, 19(3): 328-332.

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