Adverse reactions of skin drugs and concomitant liver and kidney dysfunction in inpatients

doi:10.19803/j.1672-8629.2022.03.17

Abstract

Abstract: Objective To study and analyze the correlations between clinical drug use and adverse drug reactions (ADR) related to skin drugs in order to promote rational drug use in clinic. Methods Eight hundred and fifty-eight cases of drug-induced skin ADR treated in our hospital between July 1, 2007 and December 31, 2018 were collected and statistically analyzed. Results There were 266 types of drugs involved in 858 cases of skin ADR, including antibiotic injection, blood-regulating formula and nutritional support drugs. The main routes of administration were intravenous administration (63.16%) and oral administration (25.19%). There were 747 cases of mild ADR, 71 serious ADR and 38 new ADR. 100 of these cases of skin ADR were accompanied by abnormal levels of glutamic pyruvic transaminase, glutamic oxaloacetic transaminase and serum creatinine. Conclusions kin ADR induced by drugs are mainly skin rash and pruritus, which are often accompanied by liver and kidney injury. Clinicians should assess the risk of ADR according to the patients' preexisting diseases, history of allergy and properties of various drugs, develop individualized drug delivery plans, and reduce the occurrence of ADR.

Key words: skin, adverse drug reaction, rational drug use

CLC Number:

R994.11

JIN Haobin, ZHENG Lei, YANG Jing, GUAN Yuyao, ZHANG Xiaoli. Adverse reactions of skin drugs and concomitant liver and kidney dysfunction in inpatients[J]. Chinese Journal of Pharmacovigilance, 2022, 19(3): 310-312.

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