Abstract: Objective To analyze the medication characteristics of Xiyanping injection combined in the treatment of children with pneumonia in the real world. Methods Based on HIS and LIS database of hospitalized patients from 29 hospitals in China from December 1, 2006 to June 30, 2016, the Apriori algorithm was conducted to establish the model and clementine 12.0 was conducted to analyze the characteristics and combination medication of 35 233 children who received Xiyanping injection with pneumonia. Results Children aged 0~3 years (82.83%) accounted for the largest proportion; In the real world, Xiyanping injection is mainly used for children with general conditions; The number of days in hospital was 4~14 days; For Xiyanping injection, the single intravenous dose per day was 50~100 mg; The main diagnosis of Western medicine was bronchial pneumonia, and the main diagnosis of Traditional Chinese medicine was pneumonia, asthma and cough, and the main syndromes were phlegm-heat and wind-heat; Xiyanping injection is generally combined with ambroxol (methusol) mucus dissolver, budesonide corticosteroid hormone, salbutamol selective β2-adrenergic receptor stimulant, and ipratropium bromide anticholinergic drug. Conclusion Xiyanping injection is often used in combination with mucolysis drugs, corticosteroid hormones, selective β2-adrenergic receptor promoters and anticholinergic chemicals in the treatment of children with pneumonia to provide a reference for the rational use of Xiyanping injection in clinical practice.

Key words: Xiyanping injection, children, real-world, combination drug use, clinical treatment