A real-world study of Xiyanping injection in the treatment of upper respiratory tract infections and complications in children

doi:10.19803/j.1672-8629.2022.01.09

Abstract

Abstract: Objective To analyze the preferred clinical drug combinations of Xiyanping injection in the treatment of URI in children, and explore clinically optimized schemes and routes of administration. Methods The medical data on 21 316 patients aged 0 to 14 with upper respiratory tract infection (URI) treated with Xiyanping injection between December 5, 2006 and June 20, 2016 was retrieved from the information systems of 29 tertiary hospitals across China. After standardization of the data, the Tabu search algorithm and complex network analysis were used to perform cluster module analysis. Results By dividing the clinically cured and improving population into sub-groups, the sub-groups of western medicine and traditional Chinese medicine used in the core combinations were obtained, and the relationships between the subgroups were clarified. For the treatment of URI and complications with western medicine, the obviously related sub-groups were the combination of Xiyanping with ibuprofen/acetaminophen, chlorpheniramine/loratadine, bromhexine and chlorpheniramine, or acetaminophen plus vitamin plus cimetidine plus chloral hydrate. As for TCM, the obviously related sub-groups included Xiyanping injection combined with Xiaoerchaigui antipyretic granules/Xiaochaihu granules, Xiaoerresuqing granules/Shuanghuanglian granules, Lanqin oral liquid plus stomatological spray/Kaihoujian spray, or antipyretic plus Feilike mixture. Conclusion In the real world, Xiyanping injection is usually used in combination with other drugs in the treatment of URI and its complications in children. The combined medication conforms with the guidelines. There are some regularities that facilitate clinical medication.

Key words: children, upper respiratory tract infection, Xiyanping injection, combined drug use, real-world, Tabu search algorithm

CLC Number:

R994.11

XIANG Hong, WANG Zhifei, XIE Yanming, LI Lixun, WEI Ruili, WANG Qi. A real-world study of Xiyanping injection in the treatment of upper respiratory tract infections and complications in children[J]. Chinese Journal of Pharmacovigilance, 2022, 19(1): 41-46.

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