Tentative Study of Risk Factors of Hematological Toxicity Induced by Azathioprine

doi:10.19803/j.1672-8629.2020.08.03

Abstract

Abstract: Objective To explore the risk factors of hematological toxicity induced by azathioprine drugs via a logistic model and ROC curve. Methods Related information about patients was collected from the HIS system of our hospital, and SPSS 22.0 software was used for statistical analysis. Results A total of 70 patients with rheumatism were included, 28 of whom suffered from hematological toxicity. Logistic analysis showed statistically significant differences in BMI, NRS 2002, prealbumin, and NUDT15 polymorphism. Further multivariate logistic model analysis showed that the NRS2002 score was an independent risk factor for hematological toxicity. An ROC curve was constructed with NRS2002, and patients were more likely to suffer from hematological toxicity when NRS2002 exceeded 3 points. Conclusion The risk of haematological toxicity in azathioprine-treated patients can be predicted by the NRS2002 score so that drug safety can be ensured by providing dietary guidance.

Key words: azathioprine, logistic regression model, risk factors, ROC curve

CLC Number:

R994.11

LIN Yanfang, SU Songsen, ZHOU Hong, CAI Lili, HONG Lei, LIN Zhiqiang. Tentative Study of Risk Factors of Hematological Toxicity Induced by Azathioprine[J]. Chinese Journal of Pharmacovigilance, 2020, 17(8): 461-464.

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