Research Progress on Pharmacology and Toxicology of Xuezhining

Abstract

Abstract: Objective To provid references for further rational drug use through summarizing and analyzing the research progress of the related pharmacology of Xuezhining related preparations in recent 10 years. Methods References in the last decades at home and abroad about Xuezhining related preparations were collated, analyzed and summarized. Results Xuezhining has been used for the treatment of hyperlipidemia, atherosclerosis and angina. In addition, it still has a certain effect in coronary heart disease and arrhythmia which caused by atherosclerosis. Its pharmacological effects are enhancing coronary blood circulation, softening blood vessels, improving myocardial sensitivity to cardiac glycoside action, against arrhythmia and hyperlipidemia. Its lipid-lowering mechanism is lowering plasma total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) levels and increasing high-density lipoprotein cholesterol (HDL-C) levels. There was no clinical toxicity and side effects reported. Conclusion Xuezhining affects the metabolism of lipids and reduces blood viscosity in patients with hyperlipidemia by inhibiting the body’s absorption, decomposition, excretion and deposition in the vascular wall of cholesterol and triglycerides in different ways. There were no toxic side effects reported yet.

Key words: Xuezhinig, pharmacology, toxicology

CLC Number:

R965

SHI Liang, HUANG Na-na, SUN Rong. Research Progress on Pharmacology and Toxicology of Xuezhining[J]. Chinese Journal of Pharmacovigilance, 2016, 13(6): 347-350.

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