Literature Review of 77 Cases of Adverse Drug Reactions Induced by Lamotrigine

Abstract

Abstract: Objective To investigate the general rules of lamotrigine(LTG)-related adverse drug reactions(ADRs) and clinical characteristics, and to promote rational use of LTG. Methods Literatures of LTG-induced ADRs reported in domestic and overseas pharmaceutical journals from 1994 to 2014 were retrieved and analyzed. Results 77 cases were collected in which three patients died for Stevens-Johnson syndrome and one for acute liver failure. Most of LTG-related ADRs were skin lesions which may relate to the gender, age and combination use of drugs. Conclusion It is recommended to consider the gender, age, dose, and combination use of drugs when using LTG. More attention should be paid to LTG-related ADRs to promote its rational use.

Key words: lamotrigine, adverse durg reactions, literature review

CLC Number:

R994.11

HE Xin, ZHANG Yong, XU Jin, XU Jing. Literature Review of 77 Cases of Adverse Drug Reactions Induced by Lamotrigine[J]. Chinese Journal of Pharmacovigilance, 2016, 13(5): 303-305.

References

[1] Norio Y F, Kojiro H, Koji T, et al. Comorbidity of Stevens Johnson syndrome and neutropenia associated with lamotrigine: a case report [J]. Gen Hosp Psychiatry, 2014, 36(6) : 761.e9-761.e11.
[2] Meldrum B. Action of established and novel anticonvulsant drugs on the basic mechanisms of epilepsy [J]. Epilepsy Res Suppl, 1996,11(7):67-77.
[3] 刘文丽，李红健，于鲁海，等. 拉莫三嗪致斯－约综合征及相关文献分析[J]. 中国医院药学杂志,2012,32(18): 1490-1493.
[4] 刘立民，江丹，庞露，等. 拉莫三嗪药动学及其影响因素研究进展[J]. 医药导报,2013,12(32): 1616-1619.
[5] Stefani A, Spadoni F, Siniscalchi A, et al. Lamotrigine inhibits Ca2+ currents in cortical neurons: functional implications [J]. Eur J Pharmacol, 2006, 307(1): 113-116.
[6] Sarco D P, Bourgeois B F. The safety and tolerability of newer antiepileptic drugs in children and adolescents [J]. CNS Drugs, 2010, 24(5): 399-430.
[7] Wong I C, Mawer G E, Sander J W. Factors influencing the incidence of lamotrigine-related skin rash [J]. Ann Pharmacother, 1999, 33(10): 1037-1042.
[8] Silje A, Stian L, Eylert B. Rash from Antiepileptic Drugs: Influence by Gender, Age, and Learning Disability [J]. Epilepsia, 2007, 48(7): 1360-1365.
[9] Hirsch L J, Weintraub D B, Buchsbaum R, et al. Predictors of lamotrigine-associated rash [J]. Epilepsia, 2006, 47(2):318-322.
[10] Chung W H, Hung S I, Hong H S, et al. Medical genetics: a marker for Stevens-Johnson syndrome [J]. Nature，2004,428(6982):486.
[11] An D M, Wua X T, Hua F Y, et al. Association study of lamotrigine-induced cutaneous adverse reactions and HLA-B*1502 in a Han Chinese population [J]. Epilepsy Res, 2010, 92(2-3):226-230.
[12] Lonjou C, Borot N, Sekula P, et al. A european study of HLA-B in Stevens-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs[J]. Pharmacogenet Genomics,2008,18(2): 99-107.
[13] Kazeem G R, Cox C, Aponte J, et al. High-resolution HLA genotyping and severe cutaneous adverse reactions in lamotrigine-treated patients[J]. Pharmacogenet Genomics,2009,19(9): 661-665.
[14] Pellock J M. Overview of lamotrigine and the new antiepileptic drugs:the challenge[J]. J Child Neurol, 2007,12(1): S48-S52.
[15] Stefan H, Feuerstein T J. Novel anticonvulsant drugs[J]. Pharmacol Ther, 2007,113(1):165-183.
[16] Chang Y, Yang L Y, Zhang M C, et al. Correlation of the UGT1A4 g ene polymorphism with serum concentration and therapeutic efficacy
of lamotrigine in Han Chinese of Northern China [J]. Eur J Clin Pharmacol, 2014,70(8):941-946.
[17] Barvaliya M J, Patel M K, Patel T K, et al. Toxic epidermal necrolysis
due to lamotrigine in a pediatric patient[J]. J Pharmacol Pharmacother, 2012,3(4):336-338.