Research of the Risk Factors and Practice of Drug Risk Management on Drug-induced Progressive Multifocal Leukoencephalopathy

Abstract

Abstract: Objective To investigate the etiology and risk factors, to control effectively the risk of the drug-induced progressive multifocal leukoencephalopathy (PML). Methods The etiology and pathogenesis of PML, the risk factors of drug-induced PML, and the practice of risk management were analyzed. Results The JC virus infection is etiology base of drug-induced PML, the patients who are immunosuppressed or have malfunction of the immune system are at higher risk of developing PML. Immunosuppressive medications used for long time or combination with immunomodulators could increase the risk of drug-induced PML. Conclusion The reasonable risk managements could control effectively the risk of drug-induced PML. The individual serious case report of drug-induced PML is few now, so we should enhance the abilities of monitoring and drug risk management on drug-induced PML.

Key words: drug induced, progressive multifocal leukoencephalopathy, drug risk management

CLC Number:

R994.11

FENG Hong-yun, FAN Yan, WU Gui-zhi, DONG Duo. Research of the Risk Factors and Practice of Drug Risk Management on Drug-induced Progressive Multifocal Leukoencephalopathy[J]. Chinese Journal of Pharmacovigilance, 2016, 13(8): 472-475.

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